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Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures

PURPOSE: Endogenous endophthalmitis is a severe intraocular infectious condition requiring rapid diagnosis and treatment. This study examines the incidence of fungal endophthalmitis in patients with elevated beta-D-glucan (BG) levels and those with positive blood culture and the utility of ophthalmo...

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Autores principales: Govindaraju, Viren K, Chao, Jonathan T, Duvall, Elizabeth R, Baker, Nicolas S, Fahey, Kelly M, Lee, Ramon, Williams, George A, Stec, Lori A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416315/
https://www.ncbi.nlm.nih.gov/pubmed/36035241
http://dx.doi.org/10.2147/OPTH.S362888
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author Govindaraju, Viren K
Chao, Jonathan T
Duvall, Elizabeth R
Baker, Nicolas S
Fahey, Kelly M
Lee, Ramon
Williams, George A
Stec, Lori A
author_facet Govindaraju, Viren K
Chao, Jonathan T
Duvall, Elizabeth R
Baker, Nicolas S
Fahey, Kelly M
Lee, Ramon
Williams, George A
Stec, Lori A
author_sort Govindaraju, Viren K
collection PubMed
description PURPOSE: Endogenous endophthalmitis is a severe intraocular infectious condition requiring rapid diagnosis and treatment. This study examines the incidence of fungal endophthalmitis in patients with elevated beta-D-glucan (BG) levels and those with positive blood culture and the utility of ophthalmology consultation in these patients. METHODS: Single center retrospective consecutive cohort study was conducted on patients at Beaumont Health from 2016–2021 who either had positive fungal blood cultures or an elevated BG level. RESULTS: A total of 147 patients were examined by the ophthalmology department where 30 patients had an elevated BG level and 100 patients had a positive fungal blood culture. Incidence of fungal endophthalmitis was 0% in the elevated BG group and 1.5% in the positive fungal culture group, corresponding to a relative risk ratio of 0.0 (p = 0.31). CONCLUSION: BG testing may be useful in diagnosing isolated cases outside the standard screening paradigm, however the data within this study support the conclusion that there is no compelling evidence at this time to add or use BG as a surrogate for endophthalmitis screening. Further studies are required to further elucidate the role of BG in the care of critically ill patients.
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spelling pubmed-94163152022-08-27 Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures Govindaraju, Viren K Chao, Jonathan T Duvall, Elizabeth R Baker, Nicolas S Fahey, Kelly M Lee, Ramon Williams, George A Stec, Lori A Clin Ophthalmol Original Research PURPOSE: Endogenous endophthalmitis is a severe intraocular infectious condition requiring rapid diagnosis and treatment. This study examines the incidence of fungal endophthalmitis in patients with elevated beta-D-glucan (BG) levels and those with positive blood culture and the utility of ophthalmology consultation in these patients. METHODS: Single center retrospective consecutive cohort study was conducted on patients at Beaumont Health from 2016–2021 who either had positive fungal blood cultures or an elevated BG level. RESULTS: A total of 147 patients were examined by the ophthalmology department where 30 patients had an elevated BG level and 100 patients had a positive fungal blood culture. Incidence of fungal endophthalmitis was 0% in the elevated BG group and 1.5% in the positive fungal culture group, corresponding to a relative risk ratio of 0.0 (p = 0.31). CONCLUSION: BG testing may be useful in diagnosing isolated cases outside the standard screening paradigm, however the data within this study support the conclusion that there is no compelling evidence at this time to add or use BG as a surrogate for endophthalmitis screening. Further studies are required to further elucidate the role of BG in the care of critically ill patients. Dove 2022-08-22 /pmc/articles/PMC9416315/ /pubmed/36035241 http://dx.doi.org/10.2147/OPTH.S362888 Text en © 2022 Govindaraju et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Govindaraju, Viren K
Chao, Jonathan T
Duvall, Elizabeth R
Baker, Nicolas S
Fahey, Kelly M
Lee, Ramon
Williams, George A
Stec, Lori A
Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title_full Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title_fullStr Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title_full_unstemmed Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title_short Incidence of Endogenous Fungal Endophthalmitis in Screening Dilated Exams in Patients with Elevated Beta-D-Glucan Levels versus Positive Fungal Blood Cultures
title_sort incidence of endogenous fungal endophthalmitis in screening dilated exams in patients with elevated beta-d-glucan levels versus positive fungal blood cultures
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416315/
https://www.ncbi.nlm.nih.gov/pubmed/36035241
http://dx.doi.org/10.2147/OPTH.S362888
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