The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging

Sarcopenia is an age-related systemic disease characterized by skeletal muscle aging that generally severely affects the quality of life of elderly patients. Metabolomics analysis is a powerful tool for qualitatively and quantitatively characterizing the small molecule metabolomics of various biolog...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Xuchao, Wang, Wenhao, Yang, Yijing, Lei, Yiming, Liu, Dehua, Wang, Xiaojun, Wu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416380/
https://www.ncbi.nlm.nih.gov/pubmed/36033236
http://dx.doi.org/10.2147/CIA.S376668
_version_ 1784776466150457344
author Gu, Xuchao
Wang, Wenhao
Yang, Yijing
Lei, Yiming
Liu, Dehua
Wang, Xiaojun
Wu, Tao
author_facet Gu, Xuchao
Wang, Wenhao
Yang, Yijing
Lei, Yiming
Liu, Dehua
Wang, Xiaojun
Wu, Tao
author_sort Gu, Xuchao
collection PubMed
description Sarcopenia is an age-related systemic disease characterized by skeletal muscle aging that generally severely affects the quality of life of elderly patients. Metabolomics analysis is a powerful tool for qualitatively and quantitatively characterizing the small molecule metabolomics of various biological matrices in order to clarify all key scientific problems concerning cell metabolism. The discovery of optimal therapy requires a thorough understanding of the cellular metabolic mechanism of skeletal muscle aging. In this review, the relationship between skeletal muscle mitochondria, amino acid, vitamin, lipid, adipokines, intestinal microbiota and vascular microenvironment has been separately reviewed from the perspective of metabolomics, and a new therapeutic direction has been suggested.
format Online
Article
Text
id pubmed-9416380
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-94163802022-08-27 The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging Gu, Xuchao Wang, Wenhao Yang, Yijing Lei, Yiming Liu, Dehua Wang, Xiaojun Wu, Tao Clin Interv Aging Review Sarcopenia is an age-related systemic disease characterized by skeletal muscle aging that generally severely affects the quality of life of elderly patients. Metabolomics analysis is a powerful tool for qualitatively and quantitatively characterizing the small molecule metabolomics of various biological matrices in order to clarify all key scientific problems concerning cell metabolism. The discovery of optimal therapy requires a thorough understanding of the cellular metabolic mechanism of skeletal muscle aging. In this review, the relationship between skeletal muscle mitochondria, amino acid, vitamin, lipid, adipokines, intestinal microbiota and vascular microenvironment has been separately reviewed from the perspective of metabolomics, and a new therapeutic direction has been suggested. Dove 2022-08-22 /pmc/articles/PMC9416380/ /pubmed/36033236 http://dx.doi.org/10.2147/CIA.S376668 Text en © 2022 Gu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Gu, Xuchao
Wang, Wenhao
Yang, Yijing
Lei, Yiming
Liu, Dehua
Wang, Xiaojun
Wu, Tao
The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title_full The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title_fullStr The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title_full_unstemmed The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title_short The Effect of Metabolites on Mitochondrial Functions in the Pathogenesis of Skeletal Muscle Aging
title_sort effect of metabolites on mitochondrial functions in the pathogenesis of skeletal muscle aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416380/
https://www.ncbi.nlm.nih.gov/pubmed/36033236
http://dx.doi.org/10.2147/CIA.S376668
work_keys_str_mv AT guxuchao theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wangwenhao theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT yangyijing theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT leiyiming theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT liudehua theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wangxiaojun theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wutao theeffectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT guxuchao effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wangwenhao effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT yangyijing effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT leiyiming effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT liudehua effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wangxiaojun effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging
AT wutao effectofmetabolitesonmitochondrialfunctionsinthepathogenesisofskeletalmuscleaging

Ejemplares similares