Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope...

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Detalles Bibliográficos
Autores principales: Jang, Hye Min, Jung, Myung Hwan, Lee, Jae Sang, Lee, Jun Sig, Lim, In-Cheol, Im, Hyunsik, Kim, Sang Wook, Kang, Sung-A, Cho, Won-Je, Park, Jun Kue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416411/
https://www.ncbi.nlm.nih.gov/pubmed/36014656
http://dx.doi.org/10.3390/nano12162791
Descripción
Sumario:We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope (64)Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T(2) MRI nanoprobe due to their good r(2)/r(1) ratio. Furthermore, we demonstrate that the (64)Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

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