Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope...

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Autores principales: Jang, Hye Min, Jung, Myung Hwan, Lee, Jae Sang, Lee, Jun Sig, Lim, In-Cheol, Im, Hyunsik, Kim, Sang Wook, Kang, Sung-A, Cho, Won-Je, Park, Jun Kue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416411/
https://www.ncbi.nlm.nih.gov/pubmed/36014656
http://dx.doi.org/10.3390/nano12162791
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author Jang, Hye Min
Jung, Myung Hwan
Lee, Jae Sang
Lee, Jun Sig
Lim, In-Cheol
Im, Hyunsik
Kim, Sang Wook
Kang, Sung-A
Cho, Won-Je
Park, Jun Kue
author_facet Jang, Hye Min
Jung, Myung Hwan
Lee, Jae Sang
Lee, Jun Sig
Lim, In-Cheol
Im, Hyunsik
Kim, Sang Wook
Kang, Sung-A
Cho, Won-Je
Park, Jun Kue
author_sort Jang, Hye Min
collection PubMed
description We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope (64)Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T(2) MRI nanoprobe due to their good r(2)/r(1) ratio. Furthermore, we demonstrate that the (64)Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.
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spelling pubmed-94164112022-08-27 Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability Jang, Hye Min Jung, Myung Hwan Lee, Jae Sang Lee, Jun Sig Lim, In-Cheol Im, Hyunsik Kim, Sang Wook Kang, Sung-A Cho, Won-Je Park, Jun Kue Nanomaterials (Basel) Article We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope (64)Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T(2) MRI nanoprobe due to their good r(2)/r(1) ratio. Furthermore, we demonstrate that the (64)Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system. MDPI 2022-08-14 /pmc/articles/PMC9416411/ /pubmed/36014656 http://dx.doi.org/10.3390/nano12162791 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jang, Hye Min
Jung, Myung Hwan
Lee, Jae Sang
Lee, Jun Sig
Lim, In-Cheol
Im, Hyunsik
Kim, Sang Wook
Kang, Sung-A
Cho, Won-Je
Park, Jun Kue
Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title_full Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title_fullStr Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title_full_unstemmed Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title_short Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability
title_sort chelator-free copper-64-incorporated iron oxide nanoparticles for pet/mr imaging: improved radiocopper stability and cell viability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416411/
https://www.ncbi.nlm.nih.gov/pubmed/36014656
http://dx.doi.org/10.3390/nano12162791
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