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Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa

Cannabis (Cannabis sativa L.), also known as hemp, is one of the oldest cultivated crops, grown for both its use in textile and cordage production, and its unique chemical properties. However, due to the legislation regulating cannabis cultivation, it is not a well characterized crop, especially reg...

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Autores principales: Sirangelo, Tiziana M., Ludlow, Richard A., Spadafora, Natasha D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416457/
https://www.ncbi.nlm.nih.gov/pubmed/36015485
http://dx.doi.org/10.3390/plants11162182
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author Sirangelo, Tiziana M.
Ludlow, Richard A.
Spadafora, Natasha D.
author_facet Sirangelo, Tiziana M.
Ludlow, Richard A.
Spadafora, Natasha D.
author_sort Sirangelo, Tiziana M.
collection PubMed
description Cannabis (Cannabis sativa L.), also known as hemp, is one of the oldest cultivated crops, grown for both its use in textile and cordage production, and its unique chemical properties. However, due to the legislation regulating cannabis cultivation, it is not a well characterized crop, especially regarding molecular and genetic pathways. Only recently have regulations begun to ease enough to allow more widespread cannabis research, which, coupled with the availability of cannabis genome sequences, is fuelling the interest of the scientific community. In this review, we provide a summary of cannabis molecular resources focusing on the most recent and relevant genomics, transcriptomics and metabolomics approaches and investigations. Multi-omics methods are discussed, with this combined approach being a powerful tool to identify correlations between biological processes and metabolic pathways across diverse omics layers, and to better elucidate the relationships between cannabis sub-species. The correlations between genotypes and phenotypes, as well as novel metabolites with therapeutic potential are also explored in the context of cannabis breeding programs. However, further studies are needed to fully elucidate the complex metabolomic matrix of this crop. For this reason, some key points for future research activities are discussed, relying on multi-omics approaches.
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spelling pubmed-94164572022-08-27 Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa Sirangelo, Tiziana M. Ludlow, Richard A. Spadafora, Natasha D. Plants (Basel) Review Cannabis (Cannabis sativa L.), also known as hemp, is one of the oldest cultivated crops, grown for both its use in textile and cordage production, and its unique chemical properties. However, due to the legislation regulating cannabis cultivation, it is not a well characterized crop, especially regarding molecular and genetic pathways. Only recently have regulations begun to ease enough to allow more widespread cannabis research, which, coupled with the availability of cannabis genome sequences, is fuelling the interest of the scientific community. In this review, we provide a summary of cannabis molecular resources focusing on the most recent and relevant genomics, transcriptomics and metabolomics approaches and investigations. Multi-omics methods are discussed, with this combined approach being a powerful tool to identify correlations between biological processes and metabolic pathways across diverse omics layers, and to better elucidate the relationships between cannabis sub-species. The correlations between genotypes and phenotypes, as well as novel metabolites with therapeutic potential are also explored in the context of cannabis breeding programs. However, further studies are needed to fully elucidate the complex metabolomic matrix of this crop. For this reason, some key points for future research activities are discussed, relying on multi-omics approaches. MDPI 2022-08-22 /pmc/articles/PMC9416457/ /pubmed/36015485 http://dx.doi.org/10.3390/plants11162182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sirangelo, Tiziana M.
Ludlow, Richard A.
Spadafora, Natasha D.
Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title_full Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title_fullStr Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title_full_unstemmed Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title_short Multi-Omics Approaches to Study Molecular Mechanisms in Cannabis sativa
title_sort multi-omics approaches to study molecular mechanisms in cannabis sativa
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416457/
https://www.ncbi.nlm.nih.gov/pubmed/36015485
http://dx.doi.org/10.3390/plants11162182
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