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HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men

Objective: CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antiretroviral therapy (ART). However, the effect of se...

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Autores principales: Vanpouille, Christophe, Wells, Alan, Dan, Jennifer M., Rawlings, Stephen A., Little, Susan, Fitzgerald, Wendy, Margolis, Leonid, Gianella, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416553/
https://www.ncbi.nlm.nih.gov/pubmed/36016455
http://dx.doi.org/10.3390/v14081833
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author Vanpouille, Christophe
Wells, Alan
Dan, Jennifer M.
Rawlings, Stephen A.
Little, Susan
Fitzgerald, Wendy
Margolis, Leonid
Gianella, Sara
author_facet Vanpouille, Christophe
Wells, Alan
Dan, Jennifer M.
Rawlings, Stephen A.
Little, Susan
Fitzgerald, Wendy
Margolis, Leonid
Gianella, Sara
author_sort Vanpouille, Christophe
collection PubMed
description Objective: CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antiretroviral therapy (ART). However, the effect of seminal CMV shedding in people with HIV in the earliest phase of HIV infection is not known. Methods: Using Luminex, we measured the concentration of 34 cytokines in the blood plasma of sixty-nine men who had sex with men with or without HIV and in subgroups of CMV shedders vs. non-shedders. Differences in blood plasma cytokines between groups were investigated using the multivariate supervised partial least squares discriminant analysis method. Results: Independently of CMV, we found that concentrations of IP-10, MIG, MCP-1, I-TAC 10, IL-16, and MIP-1β were modulated in the earliest phase of HIV infection compared with control individuals without HIV. In people with HIV, there was no difference in blood cytokines among CMV shedders vs. non-shedders. Conclusion: In early/acute HIV infection, asymptomatic CMV shedding in semen does not drive additional cytokine changes in blood. Early ART initiation should remain the priority, while the added benefit of CMV suppression during the various stages of HIV infection needs to be further investigated.
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spelling pubmed-94165532022-08-27 HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men Vanpouille, Christophe Wells, Alan Dan, Jennifer M. Rawlings, Stephen A. Little, Susan Fitzgerald, Wendy Margolis, Leonid Gianella, Sara Viruses Article Objective: CMV coinfection contributes to sustained immune activation in people with chronic HIV. In particular, asymptomatic CMV shedding in semen has been associated with increased local and systemic immune activation, even during suppressive antiretroviral therapy (ART). However, the effect of seminal CMV shedding in people with HIV in the earliest phase of HIV infection is not known. Methods: Using Luminex, we measured the concentration of 34 cytokines in the blood plasma of sixty-nine men who had sex with men with or without HIV and in subgroups of CMV shedders vs. non-shedders. Differences in blood plasma cytokines between groups were investigated using the multivariate supervised partial least squares discriminant analysis method. Results: Independently of CMV, we found that concentrations of IP-10, MIG, MCP-1, I-TAC 10, IL-16, and MIP-1β were modulated in the earliest phase of HIV infection compared with control individuals without HIV. In people with HIV, there was no difference in blood cytokines among CMV shedders vs. non-shedders. Conclusion: In early/acute HIV infection, asymptomatic CMV shedding in semen does not drive additional cytokine changes in blood. Early ART initiation should remain the priority, while the added benefit of CMV suppression during the various stages of HIV infection needs to be further investigated. MDPI 2022-08-21 /pmc/articles/PMC9416553/ /pubmed/36016455 http://dx.doi.org/10.3390/v14081833 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vanpouille, Christophe
Wells, Alan
Dan, Jennifer M.
Rawlings, Stephen A.
Little, Susan
Fitzgerald, Wendy
Margolis, Leonid
Gianella, Sara
HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title_full HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title_fullStr HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title_full_unstemmed HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title_short HIV but Not CMV Replication Alters the Blood Cytokine Network during Early HIV Infection in Men
title_sort hiv but not cmv replication alters the blood cytokine network during early hiv infection in men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416553/
https://www.ncbi.nlm.nih.gov/pubmed/36016455
http://dx.doi.org/10.3390/v14081833
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