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Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1

Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation. However, the underlying molecular mechanism is poorly understood. Using an in vitro vascular ce...

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Detalles Bibliográficos
Autores principales:	Zhou, Sa, Xue, Jiamin, Shan, Jingbo, Hong, Yingxiang, Zhu, Wenkang, Nie, Zhiyan, Zhang, Yujie, Ji, Nanxi, Luo, Xuegang, Zhang, Tongcun, Ma, Wenjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416570/ https://www.ncbi.nlm.nih.gov/pubmed/36014845 http://dx.doi.org/10.3390/nu14163338

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