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Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds

In this paper, near-field direct-writing melt electrospinning technology was employed to fabricate a polycaprolactone/nano-hydroxyapatite (PCL/nHA) scaffold for future applications in tissue engineering. The influences of different fabrication parameters on the structural characteristics, mechanical...

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Detalles Bibliográficos
Autores principales: Chen, Zhijun, Liu, Yanbo, Huang, Juan, Hao, Ming, Hu, Xiaodong, Qian, Xiaoming, Fan, Jintu, Yang, Hongjun, Yang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416579/
https://www.ncbi.nlm.nih.gov/pubmed/36015663
http://dx.doi.org/10.3390/polym14163404
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author Chen, Zhijun
Liu, Yanbo
Huang, Juan
Hao, Ming
Hu, Xiaodong
Qian, Xiaoming
Fan, Jintu
Yang, Hongjun
Yang, Bo
author_facet Chen, Zhijun
Liu, Yanbo
Huang, Juan
Hao, Ming
Hu, Xiaodong
Qian, Xiaoming
Fan, Jintu
Yang, Hongjun
Yang, Bo
author_sort Chen, Zhijun
collection PubMed
description In this paper, near-field direct-writing melt electrospinning technology was employed to fabricate a polycaprolactone/nano-hydroxyapatite (PCL/nHA) scaffold for future applications in tissue engineering. The influences of different fabrication parameters on the structural characteristics, mechanical properties, and thermal stability of the scaffolds were discussed. It was found that the moving speed of the receiving plate had the most significant effect on the scaffold performance, followed by the receiving distance and spinning voltage. The results also showed that these process parameters affected the fiber diameter, corresponding coefficient of variation, porosity of the composite scaffolds, and mechanical properties of the samples, including the tensile strength and fiber peeling strength. Moreover, the process parameters could influence the thermal degradation performance and melting process. Although the mass loss of the composite scaffolds was not obvious after degradation, the mechanical performance degraded severely. It was concluded that the more appropriate process parameters for preparing PCL/nHA scaffolds were a spinning voltage of −4 kV, receiving distance of 4 mm, moving speed of receiving plate of 5 mm/s, and melt temperature of 130 °C. This study proved that near-field direct-writing melt electrospinning technology is a good method to obtain PCL/nHA composite scaffolds with an excellent mechanical properties and desired morphology for future tissue engineering applications.
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spelling pubmed-94165792022-08-27 Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds Chen, Zhijun Liu, Yanbo Huang, Juan Hao, Ming Hu, Xiaodong Qian, Xiaoming Fan, Jintu Yang, Hongjun Yang, Bo Polymers (Basel) Article In this paper, near-field direct-writing melt electrospinning technology was employed to fabricate a polycaprolactone/nano-hydroxyapatite (PCL/nHA) scaffold for future applications in tissue engineering. The influences of different fabrication parameters on the structural characteristics, mechanical properties, and thermal stability of the scaffolds were discussed. It was found that the moving speed of the receiving plate had the most significant effect on the scaffold performance, followed by the receiving distance and spinning voltage. The results also showed that these process parameters affected the fiber diameter, corresponding coefficient of variation, porosity of the composite scaffolds, and mechanical properties of the samples, including the tensile strength and fiber peeling strength. Moreover, the process parameters could influence the thermal degradation performance and melting process. Although the mass loss of the composite scaffolds was not obvious after degradation, the mechanical performance degraded severely. It was concluded that the more appropriate process parameters for preparing PCL/nHA scaffolds were a spinning voltage of −4 kV, receiving distance of 4 mm, moving speed of receiving plate of 5 mm/s, and melt temperature of 130 °C. This study proved that near-field direct-writing melt electrospinning technology is a good method to obtain PCL/nHA composite scaffolds with an excellent mechanical properties and desired morphology for future tissue engineering applications. MDPI 2022-08-19 /pmc/articles/PMC9416579/ /pubmed/36015663 http://dx.doi.org/10.3390/polym14163404 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Zhijun
Liu, Yanbo
Huang, Juan
Hao, Ming
Hu, Xiaodong
Qian, Xiaoming
Fan, Jintu
Yang, Hongjun
Yang, Bo
Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title_full Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title_fullStr Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title_full_unstemmed Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title_short Influences of Process Parameters of Near-Field Direct-Writing Melt Electrospinning on Performances of Polycaprolactone/Nano-Hydroxyapatite Scaffolds
title_sort influences of process parameters of near-field direct-writing melt electrospinning on performances of polycaprolactone/nano-hydroxyapatite scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416579/
https://www.ncbi.nlm.nih.gov/pubmed/36015663
http://dx.doi.org/10.3390/polym14163404
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