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Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416620/ https://www.ncbi.nlm.nih.gov/pubmed/36006249 http://dx.doi.org/10.3390/tropicalmed7080157 |
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author | Fonte, Luis Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María de Armas, Yaxsier Calderón, Enrique J. |
author_facet | Fonte, Luis Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María de Armas, Yaxsier Calderón, Enrique J. |
author_sort | Fonte, Luis |
collection | PubMed |
description | There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection. |
format | Online Article Text |
id | pubmed-9416620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94166202022-08-27 Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa Fonte, Luis Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María de Armas, Yaxsier Calderón, Enrique J. Trop Med Infect Dis Opinion There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection. MDPI 2022-07-30 /pmc/articles/PMC9416620/ /pubmed/36006249 http://dx.doi.org/10.3390/tropicalmed7080157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Fonte, Luis Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María de Armas, Yaxsier Calderón, Enrique J. Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title | Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title_full | Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title_fullStr | Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title_full_unstemmed | Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title_short | Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa |
title_sort | overlapping of pulmonary fibrosis of postacute covid-19 syndrome and tuberculosis in the helminth coinfection setting in sub-saharan africa |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416620/ https://www.ncbi.nlm.nih.gov/pubmed/36006249 http://dx.doi.org/10.3390/tropicalmed7080157 |
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