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Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa

There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction...

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Autores principales: Fonte, Luis, Acosta, Armando, Sarmiento, María E., Norazmi, Mohd Nor, Ginori, María, de Armas, Yaxsier, Calderón, Enrique J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416620/
https://www.ncbi.nlm.nih.gov/pubmed/36006249
http://dx.doi.org/10.3390/tropicalmed7080157
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author Fonte, Luis
Acosta, Armando
Sarmiento, María E.
Norazmi, Mohd Nor
Ginori, María
de Armas, Yaxsier
Calderón, Enrique J.
author_facet Fonte, Luis
Acosta, Armando
Sarmiento, María E.
Norazmi, Mohd Nor
Ginori, María
de Armas, Yaxsier
Calderón, Enrique J.
author_sort Fonte, Luis
collection PubMed
description There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection.
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spelling pubmed-94166202022-08-27 Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa Fonte, Luis Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María de Armas, Yaxsier Calderón, Enrique J. Trop Med Infect Dis Opinion There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection. MDPI 2022-07-30 /pmc/articles/PMC9416620/ /pubmed/36006249 http://dx.doi.org/10.3390/tropicalmed7080157 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Fonte, Luis
Acosta, Armando
Sarmiento, María E.
Norazmi, Mohd Nor
Ginori, María
de Armas, Yaxsier
Calderón, Enrique J.
Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title_full Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title_fullStr Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title_full_unstemmed Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title_short Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
title_sort overlapping of pulmonary fibrosis of postacute covid-19 syndrome and tuberculosis in the helminth coinfection setting in sub-saharan africa
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416620/
https://www.ncbi.nlm.nih.gov/pubmed/36006249
http://dx.doi.org/10.3390/tropicalmed7080157
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