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New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity

IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively studied strategy in cancer treatment. We describe the design, synthesis, and characteristics of...

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Detalles Bibliográficos
Autores principales:	Talianová, Veronika, Kejík, Zdeněk, Kaplánek, Robert, Veselá, Kateřina, Abramenko, Nikita, Lacina, Lukáš, Strnadová, Karolína, Dvořánková, Barbora, Martásek, Pavel, Masařík, Michal, Megová, Magdalena Houdová, Bušek, Petr, Křížová, Jana, Zdražilová, Lucie, Hansíková, Hana, Vlčák, Erik, Filimonenko, Vlada, Šedo, Aleksi, Smetana, Karel, Jakubek, Milan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416741/ https://www.ncbi.nlm.nih.gov/pubmed/36015338 http://dx.doi.org/10.3390/pharmaceutics14081712

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