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Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine

Methylmalonic acid (MMA) is a very short dicarboxylic acid (methylpropanedioic acid; CH(3)CH(COOH)(2); pK(a1), 3.07; pK(a2), 5.76) associated with vitamin B(12) deficiency and many other patho-physiological conditions. In this work, we investigated several carboxylic groups-specific derivatization r...

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Detalles Bibliográficos
Autores principales:	Bollenbach, Alexander, Baskal, Svetlana, Mels, Catharina, Kruger, Ruan, Tsikas, Dimitrios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416772/ https://www.ncbi.nlm.nih.gov/pubmed/36014446 http://dx.doi.org/10.3390/molecules27165202

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