Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes

An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.

Detalles Bibliográficos
Autores principales: Philippova, Anna N., Vorobyeva, Daria V., Gribanov, Pavel S., Godovikov, Ivan A., Osipov, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416787/
https://www.ncbi.nlm.nih.gov/pubmed/36014436
http://dx.doi.org/10.3390/molecules27165195
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author Philippova, Anna N.
Vorobyeva, Daria V.
Gribanov, Pavel S.
Godovikov, Ivan A.
Osipov, Sergey N.
author_facet Philippova, Anna N.
Vorobyeva, Daria V.
Gribanov, Pavel S.
Godovikov, Ivan A.
Osipov, Sergey N.
author_sort Philippova, Anna N.
collection PubMed
description An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines.
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spelling pubmed-94167872022-08-27 Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes Philippova, Anna N. Vorobyeva, Daria V. Gribanov, Pavel S. Godovikov, Ivan A. Osipov, Sergey N. Molecules Article An efficient method for the selective preparation of trifluoromethyl-substituted azepin-2-carboxylates and their phosphorous analogues has been developed via Cu(I)-catalyzed tandem amination/cyclization reaction of functionalized allenynes with primary and secondary amines. MDPI 2022-08-15 /pmc/articles/PMC9416787/ /pubmed/36014436 http://dx.doi.org/10.3390/molecules27165195 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Philippova, Anna N.
Vorobyeva, Daria V.
Gribanov, Pavel S.
Godovikov, Ivan A.
Osipov, Sergey N.
Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title_full Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title_fullStr Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title_full_unstemmed Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title_short Synthesis of Functionalized Azepines via Cu(I)-Catalyzed Tandem Amination/Cyclization Reaction of Fluorinated Allenynes
title_sort synthesis of functionalized azepines via cu(i)-catalyzed tandem amination/cyclization reaction of fluorinated allenynes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416787/
https://www.ncbi.nlm.nih.gov/pubmed/36014436
http://dx.doi.org/10.3390/molecules27165195
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