The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster

The effect of replacing guanosines with inosines in the two stabilizing strands (5′-CACCTAGCGA-3′) of the NIR emissive DNA-Ag(16)NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence d...

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Detalles Bibliográficos
Autores principales: Cerretani, Cecilia, Liisberg, Mikkel B., Rück, Vanessa, Kondo, Jiro, Vosch, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416947/
https://www.ncbi.nlm.nih.gov/pubmed/36132821
http://dx.doi.org/10.1039/d2na00325b
Descripción
Sumario:The effect of replacing guanosines with inosines in the two stabilizing strands (5′-CACCTAGCGA-3′) of the NIR emissive DNA-Ag(16)NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes.

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