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The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster
The effect of replacing guanosines with inosines in the two stabilizing strands (5′-CACCTAGCGA-3′) of the NIR emissive DNA-Ag(16)NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416947/ https://www.ncbi.nlm.nih.gov/pubmed/36132821 http://dx.doi.org/10.1039/d2na00325b |
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author | Cerretani, Cecilia Liisberg, Mikkel B. Rück, Vanessa Kondo, Jiro Vosch, Tom |
author_facet | Cerretani, Cecilia Liisberg, Mikkel B. Rück, Vanessa Kondo, Jiro Vosch, Tom |
author_sort | Cerretani, Cecilia |
collection | PubMed |
description | The effect of replacing guanosines with inosines in the two stabilizing strands (5′-CACCTAGCGA-3′) of the NIR emissive DNA-Ag(16)NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes. |
format | Online Article Text |
id | pubmed-9416947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-94169472022-09-20 The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster Cerretani, Cecilia Liisberg, Mikkel B. Rück, Vanessa Kondo, Jiro Vosch, Tom Nanoscale Adv Chemistry The effect of replacing guanosines with inosines in the two stabilizing strands (5′-CACCTAGCGA-3′) of the NIR emissive DNA-Ag(16)NC was investigated. The spectroscopic behavior of the inosine mutants is position-dependent: when the guanosine in position 7 was exchanged, the nanosecond fluorescence decay time shortened, while having the inosine in position 9 made the decay time longer. Thanks to structural information gained from single crystal X-ray diffraction measurements, it was possible to propose a mechanistic origin for the observed changes. RSC 2022-06-20 /pmc/articles/PMC9416947/ /pubmed/36132821 http://dx.doi.org/10.1039/d2na00325b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Cerretani, Cecilia Liisberg, Mikkel B. Rück, Vanessa Kondo, Jiro Vosch, Tom The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title | The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title_full | The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title_fullStr | The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title_full_unstemmed | The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title_short | The effect of inosine on the spectroscopic properties and crystal structure of a NIR-emitting DNA-stabilized silver nanocluster |
title_sort | effect of inosine on the spectroscopic properties and crystal structure of a nir-emitting dna-stabilized silver nanocluster |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9416947/ https://www.ncbi.nlm.nih.gov/pubmed/36132821 http://dx.doi.org/10.1039/d2na00325b |
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