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“PP-type” self-assembling peptides with superior rheological properties

The ionic-complementary self-assembling peptides discovered by Zhang Shuguang have solution-to-gel (sol–gel) transition capacity and one such peptide RADA16 has been commercialized into hemostatic agents. However, their sol–gel transition ability was not obvious because the peptide aqueous solution...

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Autores principales: Li, Fangmin, Gao, Lichang, Zhang, Xudong, Wang, Pin, Liu, Yuanxue, Feng, Jinhui, Zhang, Chunxia, Zhao, Chengru, Zhang, Shang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417066/
https://www.ncbi.nlm.nih.gov/pubmed/36133953
http://dx.doi.org/10.1039/d1na00534k
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author Li, Fangmin
Gao, Lichang
Zhang, Xudong
Wang, Pin
Liu, Yuanxue
Feng, Jinhui
Zhang, Chunxia
Zhao, Chengru
Zhang, Shang
author_facet Li, Fangmin
Gao, Lichang
Zhang, Xudong
Wang, Pin
Liu, Yuanxue
Feng, Jinhui
Zhang, Chunxia
Zhao, Chengru
Zhang, Shang
author_sort Li, Fangmin
collection PubMed
description The ionic-complementary self-assembling peptides discovered by Zhang Shuguang have solution-to-gel (sol–gel) transition capacity and one such peptide RADA16 has been commercialized into hemostatic agents. However, their sol–gel transition ability was not obvious because the peptide aqueous solution with a concentration greater than 1% w/v appeared to be thick and viscous. The current report describes PP-type self-assembling peptides. In addition to the ionic-complementary sequence, they have prolines at both ends of the sequence. This feature has led to better solubility, lower viscosity of the peptide solution, and simplified synthesis and purification processes while maintaining the great gelling performance of the ionic-complementary peptides. The PP-type peptides self-assembled into a well-organized nanofiber scaffold as shown by TEM. Among the PP-type peptides, the PRVDP9 sequence peptide was tested as a hemostatic agent and a mucosal elevating agent. The results were comparable to the classic RADA16. The PP-type self-assembling peptides have superior sol–gel transition ability. Therefore, it is predicted that they will be more suitable to be transported through catheters or endoscopes and have higher commercialization potential as compared with the classic self-assembling peptide sequences.
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spelling pubmed-94170662022-09-20 “PP-type” self-assembling peptides with superior rheological properties Li, Fangmin Gao, Lichang Zhang, Xudong Wang, Pin Liu, Yuanxue Feng, Jinhui Zhang, Chunxia Zhao, Chengru Zhang, Shang Nanoscale Adv Chemistry The ionic-complementary self-assembling peptides discovered by Zhang Shuguang have solution-to-gel (sol–gel) transition capacity and one such peptide RADA16 has been commercialized into hemostatic agents. However, their sol–gel transition ability was not obvious because the peptide aqueous solution with a concentration greater than 1% w/v appeared to be thick and viscous. The current report describes PP-type self-assembling peptides. In addition to the ionic-complementary sequence, they have prolines at both ends of the sequence. This feature has led to better solubility, lower viscosity of the peptide solution, and simplified synthesis and purification processes while maintaining the great gelling performance of the ionic-complementary peptides. The PP-type peptides self-assembled into a well-organized nanofiber scaffold as shown by TEM. Among the PP-type peptides, the PRVDP9 sequence peptide was tested as a hemostatic agent and a mucosal elevating agent. The results were comparable to the classic RADA16. The PP-type self-assembling peptides have superior sol–gel transition ability. Therefore, it is predicted that they will be more suitable to be transported through catheters or endoscopes and have higher commercialization potential as compared with the classic self-assembling peptide sequences. RSC 2021-09-03 /pmc/articles/PMC9417066/ /pubmed/36133953 http://dx.doi.org/10.1039/d1na00534k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Fangmin
Gao, Lichang
Zhang, Xudong
Wang, Pin
Liu, Yuanxue
Feng, Jinhui
Zhang, Chunxia
Zhao, Chengru
Zhang, Shang
“PP-type” self-assembling peptides with superior rheological properties
title “PP-type” self-assembling peptides with superior rheological properties
title_full “PP-type” self-assembling peptides with superior rheological properties
title_fullStr “PP-type” self-assembling peptides with superior rheological properties
title_full_unstemmed “PP-type” self-assembling peptides with superior rheological properties
title_short “PP-type” self-assembling peptides with superior rheological properties
title_sort “pp-type” self-assembling peptides with superior rheological properties
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417066/
https://www.ncbi.nlm.nih.gov/pubmed/36133953
http://dx.doi.org/10.1039/d1na00534k
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