Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

Detalles Bibliográficos
Autores principales: Hobson, James J., Curley, Paul, Savage, Alison C., Al-khouja, Amer, Siccardi, Marco, Flexner, Charles, Meyers, Caren Freel, Owen, Andrew, Rannard, Steve P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417103/
https://www.ncbi.nlm.nih.gov/pubmed/36134394
http://dx.doi.org/10.1039/c9na00529c
Descripción
Sumario:The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

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