Time Taken to Detect and Respond to Polio Outbreaks in Africa and the Potential Impact of Direct Molecular Detection and Nanopore Sequencing

BACKGROUND: Detection of poliovirus outbreaks relies on a complex laboratory algorithm of cell-culture, polymerase chain reaction (PCR), and sequencing to distinguish wild-type and vaccine-derived polioviruses (VDPV) from Sabin-like strains. We investigated the potential for direct molecular detecti...

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Detalles Bibliográficos
Autores principales: Shaw, Alexander G, Cooper, Laura V, Gumede, Nicksy, Bandyopadhyay, Ananda S, Grassly, Nicholas C, Blake, Isobel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417130/
https://www.ncbi.nlm.nih.gov/pubmed/34623444
http://dx.doi.org/10.1093/infdis/jiab518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417130/
https://www.ncbi.nlm.nih.gov/pubmed/34623444
http://dx.doi.org/10.1093/infdis/jiab518

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