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Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells
Aging is accompanied by functional loss of many cellular pathways, creating an increased risk of many age-related complications (ARC). Aging causes stem cell exhaustion with a concomitant increase in cellular dysfunction. Recently, interest in senotherapeutics has been growing rapidly to promote hea...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417221/ https://www.ncbi.nlm.nih.gov/pubmed/35951373 http://dx.doi.org/10.18632/aging.204210 |
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author | Ho, Tsung-Jung Goswami, Debakshee Kuo, Wei-Wen Kuo, Chia-Hua Yen, Shih Cheng Lin, Pi-Yu Lin, Shinn-Zong Hsieh, Dennis Jine-Yuan Shibu, Marthandam Asokan Huang, Chih-Yang |
author_facet | Ho, Tsung-Jung Goswami, Debakshee Kuo, Wei-Wen Kuo, Chia-Hua Yen, Shih Cheng Lin, Pi-Yu Lin, Shinn-Zong Hsieh, Dennis Jine-Yuan Shibu, Marthandam Asokan Huang, Chih-Yang |
author_sort | Ho, Tsung-Jung |
collection | PubMed |
description | Aging is accompanied by functional loss of many cellular pathways, creating an increased risk of many age-related complications (ARC). Aging causes stem cell exhaustion with a concomitant increase in cellular dysfunction. Recently, interest in senotherapeutics has been growing rapidly to promote healthy aging and as an intervention for ARCs. This research focused on screening the senomorphic properties of Artemisia argyi, as an emerging strategy for longevity, and prevention or treatment of ARCs. In this study, we aimed to find the clinical efficacy of daily consumption of Artemisia argyi water extract (AAW) on aging. In vitro 0.1μM Doxorubicin induced senescent human adipose derived mesenchymal stem cells was treated with different concentrations of AAW to show its anti-aging effect. 15 months old SHR rats (n=6) were treated with 7.9 mg/ml AAW for 4 weeks and anti-aging effect was evaluated. In vitro study showed the protective effect of AAW in telomere shortening and helps in maintaining a balance in the expression of anti-aging protein Klotho and TERT. AAW effectively reduced mitochondrial superoxide and also provided a protective shield against senescence markers like over-expression of p21 and formation of double strand breaks, which is known to cause premature aging. Moreover, animal studies indicated that AAW promoted the expression of Klotho in naturally aging rats. In addition, AAW successfully restored the decline cardiac function and improved the grip strength and memory of aging rat. These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health. |
format | Online Article Text |
id | pubmed-9417221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-94172212022-08-29 Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells Ho, Tsung-Jung Goswami, Debakshee Kuo, Wei-Wen Kuo, Chia-Hua Yen, Shih Cheng Lin, Pi-Yu Lin, Shinn-Zong Hsieh, Dennis Jine-Yuan Shibu, Marthandam Asokan Huang, Chih-Yang Aging (Albany NY) Research Paper Aging is accompanied by functional loss of many cellular pathways, creating an increased risk of many age-related complications (ARC). Aging causes stem cell exhaustion with a concomitant increase in cellular dysfunction. Recently, interest in senotherapeutics has been growing rapidly to promote healthy aging and as an intervention for ARCs. This research focused on screening the senomorphic properties of Artemisia argyi, as an emerging strategy for longevity, and prevention or treatment of ARCs. In this study, we aimed to find the clinical efficacy of daily consumption of Artemisia argyi water extract (AAW) on aging. In vitro 0.1μM Doxorubicin induced senescent human adipose derived mesenchymal stem cells was treated with different concentrations of AAW to show its anti-aging effect. 15 months old SHR rats (n=6) were treated with 7.9 mg/ml AAW for 4 weeks and anti-aging effect was evaluated. In vitro study showed the protective effect of AAW in telomere shortening and helps in maintaining a balance in the expression of anti-aging protein Klotho and TERT. AAW effectively reduced mitochondrial superoxide and also provided a protective shield against senescence markers like over-expression of p21 and formation of double strand breaks, which is known to cause premature aging. Moreover, animal studies indicated that AAW promoted the expression of Klotho in naturally aging rats. In addition, AAW successfully restored the decline cardiac function and improved the grip strength and memory of aging rat. These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health. Impact Journals 2022-08-09 /pmc/articles/PMC9417221/ /pubmed/35951373 http://dx.doi.org/10.18632/aging.204210 Text en Copyright: © 2022 Ho et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ho, Tsung-Jung Goswami, Debakshee Kuo, Wei-Wen Kuo, Chia-Hua Yen, Shih Cheng Lin, Pi-Yu Lin, Shinn-Zong Hsieh, Dennis Jine-Yuan Shibu, Marthandam Asokan Huang, Chih-Yang Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title | Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title_full | Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title_fullStr | Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title_full_unstemmed | Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title_short | Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
title_sort | artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417221/ https://www.ncbi.nlm.nih.gov/pubmed/35951373 http://dx.doi.org/10.18632/aging.204210 |
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