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Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

During embryonic development cells acquire identity as they proliferate, implying that an intrinsic facet of cell fate choice requires coupling lineage decisions to cell division. How is the cell cycle regulated to promote or suppress heterogeneity and differentiation? We explore this question combi...

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Detalles Bibliográficos
Autores principales:	Perera, Marta, Nissen, Silas Boye, Proks, Martin, Pozzi, Sara, Monteiro, Rita S, Trusina, Ala, Brickman, Joshua M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417417/ https://www.ncbi.nlm.nih.gov/pubmed/35969041 http://dx.doi.org/10.7554/eLife.78967

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