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PH domain-mediated autoinhibition and oncogenic activation of Akt

Akt is a Ser/Thr protein kinase that plays a central role in metabolism and cancer. Regulation of Akt’s activity involves an autoinhibitory intramolecular interaction between its pleckstrin homology (PH) domain and its kinase domain that can be relieved by C-tail phosphorylation. PH domain mutant E1...

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Detalles Bibliográficos
Autores principales:	Bae, Hwan, Viennet, Thibault, Park, Eunyoung, Chu, Nam, Salguero, Antonieta, Eck, Michael J, Arthanari, Haribabu, Cole, Philip A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417420/ https://www.ncbi.nlm.nih.gov/pubmed/35968932 http://dx.doi.org/10.7554/eLife.80148

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