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Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression
The special microenvironment of a solid tumor promotes the orientation and colonization of facultative anaerobes. Intratumoral bacterial infection disrupts the local vascular system to form a thrombus, resulting in darkened tumor sites and enhanced near-infrared absorption. Based on this, we constru...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417531/ https://www.ncbi.nlm.nih.gov/pubmed/36134371 http://dx.doi.org/10.1039/d1na00857a |
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author | Xu, Wenxuan Ren, Debao Yu, Zimeng Hou, Jia Huang, Fan Gan, Tingfang Ji, Ping Zhang, Cheng Ma, Lixin Hu, Yunhong |
author_facet | Xu, Wenxuan Ren, Debao Yu, Zimeng Hou, Jia Huang, Fan Gan, Tingfang Ji, Ping Zhang, Cheng Ma, Lixin Hu, Yunhong |
author_sort | Xu, Wenxuan |
collection | PubMed |
description | The special microenvironment of a solid tumor promotes the orientation and colonization of facultative anaerobes. Intratumoral bacterial infection disrupts the local vascular system to form a thrombus, resulting in darkened tumor sites and enhanced near-infrared absorption. Based on this, we constructed thermally-induced bacteria (TIB) to express programmed cell death protein 1 (PD1) at tumor tissue sites. Under laser irradiation, the elevated temperature at the tumor site not only caused damage to tumor cells but also induced the expression of PD1. Expressed PD1 bound to the ligand of PD1 (PD-L1) on the tumor cell surface and facilitated its internalization and reduction, thereby relieving immune suppression in the tumor microenvironment. Through the combined effects of photothermal therapy and immune activation, the ingenious TIB@PD1 approach greatly inhibited the proliferation and metastasis of tumor cells. Therefore, bacteria-based photothermal immunotherapy represents an appealing method for tumor therapy with good specificity and selectivity. |
format | Online Article Text |
id | pubmed-9417531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-94175312022-09-20 Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression Xu, Wenxuan Ren, Debao Yu, Zimeng Hou, Jia Huang, Fan Gan, Tingfang Ji, Ping Zhang, Cheng Ma, Lixin Hu, Yunhong Nanoscale Adv Chemistry The special microenvironment of a solid tumor promotes the orientation and colonization of facultative anaerobes. Intratumoral bacterial infection disrupts the local vascular system to form a thrombus, resulting in darkened tumor sites and enhanced near-infrared absorption. Based on this, we constructed thermally-induced bacteria (TIB) to express programmed cell death protein 1 (PD1) at tumor tissue sites. Under laser irradiation, the elevated temperature at the tumor site not only caused damage to tumor cells but also induced the expression of PD1. Expressed PD1 bound to the ligand of PD1 (PD-L1) on the tumor cell surface and facilitated its internalization and reduction, thereby relieving immune suppression in the tumor microenvironment. Through the combined effects of photothermal therapy and immune activation, the ingenious TIB@PD1 approach greatly inhibited the proliferation and metastasis of tumor cells. Therefore, bacteria-based photothermal immunotherapy represents an appealing method for tumor therapy with good specificity and selectivity. RSC 2022-02-07 /pmc/articles/PMC9417531/ /pubmed/36134371 http://dx.doi.org/10.1039/d1na00857a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Xu, Wenxuan Ren, Debao Yu, Zimeng Hou, Jia Huang, Fan Gan, Tingfang Ji, Ping Zhang, Cheng Ma, Lixin Hu, Yunhong Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title | Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title_full | Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title_fullStr | Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title_full_unstemmed | Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title_short | Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression |
title_sort | bacteria-mediated tumor immunotherapy via photothermally-programmed pd1 expression |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417531/ https://www.ncbi.nlm.nih.gov/pubmed/36134371 http://dx.doi.org/10.1039/d1na00857a |
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