Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents

Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd(3+)–ferritin nanoparticles at (sub)nanomolar concentrations of Gd(3+) under physiological conditions. We describe their structu...

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Detalles Bibliográficos
Autores principales: Neburkova, Jitka, Rulseh, Aaron M., Chang, Shery L. Y., Raabova, Helena, Vejpravova, Jana, Dracinsky, Martin, Tarabek, Jan, Kotek, Jan, Pingle, Mohan, Majer, Pavel, Vymazal, Josef, Cigler, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417687/
https://www.ncbi.nlm.nih.gov/pubmed/36133872
http://dx.doi.org/10.1039/c9na00567f
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author Neburkova, Jitka
Rulseh, Aaron M.
Chang, Shery L. Y.
Raabova, Helena
Vejpravova, Jana
Dracinsky, Martin
Tarabek, Jan
Kotek, Jan
Pingle, Mohan
Majer, Pavel
Vymazal, Josef
Cigler, Petr
author_facet Neburkova, Jitka
Rulseh, Aaron M.
Chang, Shery L. Y.
Raabova, Helena
Vejpravova, Jana
Dracinsky, Martin
Tarabek, Jan
Kotek, Jan
Pingle, Mohan
Majer, Pavel
Vymazal, Josef
Cigler, Petr
author_sort Neburkova, Jitka
collection PubMed
description Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd(3+)–ferritin nanoparticles at (sub)nanomolar concentrations of Gd(3+) under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.
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spelling pubmed-94176872022-09-20 Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents Neburkova, Jitka Rulseh, Aaron M. Chang, Shery L. Y. Raabova, Helena Vejpravova, Jana Dracinsky, Martin Tarabek, Jan Kotek, Jan Pingle, Mohan Majer, Pavel Vymazal, Josef Cigler, Petr Nanoscale Adv Chemistry Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd(3+)–ferritin nanoparticles at (sub)nanomolar concentrations of Gd(3+) under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI. RSC 2020-08-31 /pmc/articles/PMC9417687/ /pubmed/36133872 http://dx.doi.org/10.1039/c9na00567f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Neburkova, Jitka
Rulseh, Aaron M.
Chang, Shery L. Y.
Raabova, Helena
Vejpravova, Jana
Dracinsky, Martin
Tarabek, Jan
Kotek, Jan
Pingle, Mohan
Majer, Pavel
Vymazal, Josef
Cigler, Petr
Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title_full Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title_fullStr Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title_full_unstemmed Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title_short Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
title_sort formation of gadolinium–ferritin from clinical magnetic resonance contrast agents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417687/
https://www.ncbi.nlm.nih.gov/pubmed/36133872
http://dx.doi.org/10.1039/c9na00567f
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