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Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy

AIMS: To assess if patients with type 2 diabetes mellitus (DM2) are: a) at excess risk of undergoing testing, contracting, and dying from SARS-CoV-2 infection compared to the general population; b) whether cardiovascular diseases (CAVDs) contribute to COVID-19-related death; and c) what is the effec...

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Autores principales: Djuric, Olivera, Ottone, Marta, Vicentini, Massimo, Venturelli, Francesco, Pezzarossi, Annamaria, Manicardi, Valeria, Greci, Marina, Giorgi Rossi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417741/
https://www.ncbi.nlm.nih.gov/pubmed/36030900
http://dx.doi.org/10.1016/j.diabres.2022.110051
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author Djuric, Olivera
Ottone, Marta
Vicentini, Massimo
Venturelli, Francesco
Pezzarossi, Annamaria
Manicardi, Valeria
Greci, Marina
Giorgi Rossi, Paolo
author_facet Djuric, Olivera
Ottone, Marta
Vicentini, Massimo
Venturelli, Francesco
Pezzarossi, Annamaria
Manicardi, Valeria
Greci, Marina
Giorgi Rossi, Paolo
author_sort Djuric, Olivera
collection PubMed
description AIMS: To assess if patients with type 2 diabetes mellitus (DM2) are: a) at excess risk of undergoing testing, contracting, and dying from SARS-CoV-2 infection compared to the general population; b) whether cardiovascular diseases (CAVDs) contribute to COVID-19-related death; and c) what is the effect of DM2 duration and control on COVID-19-related death. METHODS: This population-based study involved all 449,440 adult residents of the Reggio Emilia province, Italy. DM2 patients were divided in groups by COVID testing, presence of CAVDs and COVID death. Several mediation analyses were performed. RESULTS: Patients with DM2 had an increased likelihood of being tested (Odds ratio, OR 1.27 95 %CI 1.23–1.30), testing positive (OR 1.21 95 %CI 1.16–1.26) and dying from COVID-19 (OR 1.75 95 %CI 1.54–2.00). COVID-19-related death was almost three times higher among obese vs non-obese patients with DM2 (OR 4.3 vs 1.6, respectively). For COVID-19 death, CAVDs mediated a) just 5.1 % of the total effect of DM2, b) 40 % of the effect of DM2 duration, and c) did not mediate the effect of glycemic control. CONCLUSIONS: For COVID-19-related deaths in DM2 patients, the effect is mostly direct, obesity amplifies it, DM2 control and duration are important predictors, while CAVDs only slightly mediates it.
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spelling pubmed-94177412022-08-30 Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy Djuric, Olivera Ottone, Marta Vicentini, Massimo Venturelli, Francesco Pezzarossi, Annamaria Manicardi, Valeria Greci, Marina Giorgi Rossi, Paolo Diabetes Res Clin Pract Article AIMS: To assess if patients with type 2 diabetes mellitus (DM2) are: a) at excess risk of undergoing testing, contracting, and dying from SARS-CoV-2 infection compared to the general population; b) whether cardiovascular diseases (CAVDs) contribute to COVID-19-related death; and c) what is the effect of DM2 duration and control on COVID-19-related death. METHODS: This population-based study involved all 449,440 adult residents of the Reggio Emilia province, Italy. DM2 patients were divided in groups by COVID testing, presence of CAVDs and COVID death. Several mediation analyses were performed. RESULTS: Patients with DM2 had an increased likelihood of being tested (Odds ratio, OR 1.27 95 %CI 1.23–1.30), testing positive (OR 1.21 95 %CI 1.16–1.26) and dying from COVID-19 (OR 1.75 95 %CI 1.54–2.00). COVID-19-related death was almost three times higher among obese vs non-obese patients with DM2 (OR 4.3 vs 1.6, respectively). For COVID-19 death, CAVDs mediated a) just 5.1 % of the total effect of DM2, b) 40 % of the effect of DM2 duration, and c) did not mediate the effect of glycemic control. CONCLUSIONS: For COVID-19-related deaths in DM2 patients, the effect is mostly direct, obesity amplifies it, DM2 control and duration are important predictors, while CAVDs only slightly mediates it. Elsevier B.V. 2022-09 2022-08-27 /pmc/articles/PMC9417741/ /pubmed/36030900 http://dx.doi.org/10.1016/j.diabres.2022.110051 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Djuric, Olivera
Ottone, Marta
Vicentini, Massimo
Venturelli, Francesco
Pezzarossi, Annamaria
Manicardi, Valeria
Greci, Marina
Giorgi Rossi, Paolo
Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title_full Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title_fullStr Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title_full_unstemmed Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title_short Diabetes and COVID-19 testing, positivity, and mortality: A population-wide study in Northern Italy
title_sort diabetes and covid-19 testing, positivity, and mortality: a population-wide study in northern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417741/
https://www.ncbi.nlm.nih.gov/pubmed/36030900
http://dx.doi.org/10.1016/j.diabres.2022.110051
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