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Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study
BACKGROUND: Coronavirus disease 2019 (COVID-19) is a potentially fatal pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially those of novel SARS-CoV-2 variants and infection has affected over 700 million people globally. METHODS: This retrospective, descriptive...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417765/ https://www.ncbi.nlm.nih.gov/pubmed/36033569 http://dx.doi.org/10.1155/2022/1399268 |
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author | Bi, DeWu Chen, ZhenCheng Wei, ShanQiu Xie, ZhouHua Zang, Ning Mo, LiDa Liu, ZeDuan Wang, YuanLi Cao, LiangLi Zhao, FeiJun Lin, YanRong Qin, YaQin Tang, XiKe Su, HanZhen Zhou, JinAi Liang, JuanYing Lan, ZhenXu Lin, Lü Xi, ShaoYong Luo, XiaoCheng Ma, QiuYing Pang, XiaoFeng Luo, XiaoLu |
author_facet | Bi, DeWu Chen, ZhenCheng Wei, ShanQiu Xie, ZhouHua Zang, Ning Mo, LiDa Liu, ZeDuan Wang, YuanLi Cao, LiangLi Zhao, FeiJun Lin, YanRong Qin, YaQin Tang, XiKe Su, HanZhen Zhou, JinAi Liang, JuanYing Lan, ZhenXu Lin, Lü Xi, ShaoYong Luo, XiaoCheng Ma, QiuYing Pang, XiaoFeng Luo, XiaoLu |
author_sort | Bi, DeWu |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) is a potentially fatal pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially those of novel SARS-CoV-2 variants and infection has affected over 700 million people globally. METHODS: This retrospective, descriptive study included 118 patients admitted with SARS-CoV-2 infection as confirmed by real-time reverse transcription polymerase chain reaction. RESULTS: The median duration of detectable SARS-CoV-2 infection in patients with high ALT, AST, and PLT/LYMPH, or low CD4+, CD8+, and PLT/MONO was considerably longer. In the risk factor model, multivariate analysis was performed for the estimation of ALT (HR, 0.54; 95% CI, 0.36-0.81), AST (HR, 0.56; 95% CI, 0.34-0.93), CD4+ (HR,0.77; 95% CI, 0.48-1.24), CD8+ (HR,0.64; 95% CI, 0.37-1.11), PLT/LYMPH (HR, 1.16; 95% CI, 0.76-1.77), and PLT/MONO (HR, 0.64; 95% CI, 0.43-0.94). CONCLUSIONS: The longer viral RNA duration was associated with a higher International Prognostic Index score (p = 0.0013), demonstrating for the first time that multivariate features of the bioindicators closely associated with SARS-CoV-2-infected patients clear the virus. |
format | Online Article Text |
id | pubmed-9417765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94177652022-08-27 Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study Bi, DeWu Chen, ZhenCheng Wei, ShanQiu Xie, ZhouHua Zang, Ning Mo, LiDa Liu, ZeDuan Wang, YuanLi Cao, LiangLi Zhao, FeiJun Lin, YanRong Qin, YaQin Tang, XiKe Su, HanZhen Zhou, JinAi Liang, JuanYing Lan, ZhenXu Lin, Lü Xi, ShaoYong Luo, XiaoCheng Ma, QiuYing Pang, XiaoFeng Luo, XiaoLu Biomed Res Int Research Article BACKGROUND: Coronavirus disease 2019 (COVID-19) is a potentially fatal pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially those of novel SARS-CoV-2 variants and infection has affected over 700 million people globally. METHODS: This retrospective, descriptive study included 118 patients admitted with SARS-CoV-2 infection as confirmed by real-time reverse transcription polymerase chain reaction. RESULTS: The median duration of detectable SARS-CoV-2 infection in patients with high ALT, AST, and PLT/LYMPH, or low CD4+, CD8+, and PLT/MONO was considerably longer. In the risk factor model, multivariate analysis was performed for the estimation of ALT (HR, 0.54; 95% CI, 0.36-0.81), AST (HR, 0.56; 95% CI, 0.34-0.93), CD4+ (HR,0.77; 95% CI, 0.48-1.24), CD8+ (HR,0.64; 95% CI, 0.37-1.11), PLT/LYMPH (HR, 1.16; 95% CI, 0.76-1.77), and PLT/MONO (HR, 0.64; 95% CI, 0.43-0.94). CONCLUSIONS: The longer viral RNA duration was associated with a higher International Prognostic Index score (p = 0.0013), demonstrating for the first time that multivariate features of the bioindicators closely associated with SARS-CoV-2-infected patients clear the virus. Hindawi 2022-08-19 /pmc/articles/PMC9417765/ /pubmed/36033569 http://dx.doi.org/10.1155/2022/1399268 Text en Copyright © 2022 DeWu Bi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bi, DeWu Chen, ZhenCheng Wei, ShanQiu Xie, ZhouHua Zang, Ning Mo, LiDa Liu, ZeDuan Wang, YuanLi Cao, LiangLi Zhao, FeiJun Lin, YanRong Qin, YaQin Tang, XiKe Su, HanZhen Zhou, JinAi Liang, JuanYing Lan, ZhenXu Lin, Lü Xi, ShaoYong Luo, XiaoCheng Ma, QiuYing Pang, XiaoFeng Luo, XiaoLu Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title | Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title_full | Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title_fullStr | Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title_full_unstemmed | Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title_short | Viral Dynamic Surveillance in COVID-19 Patients: A Cohort Study |
title_sort | viral dynamic surveillance in covid-19 patients: a cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417765/ https://www.ncbi.nlm.nih.gov/pubmed/36033569 http://dx.doi.org/10.1155/2022/1399268 |
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