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Preclinical Evaluation of the Tumorigenic and Immunomodulatory Properties of Human Bone Marrow Mesenchymal Stromal Cell Populations with Clonal Trisomy 5

Cytogenetic aberrations may emerge in human mesenchymal stromal cells (MSC) during ex vivo expansion for cell therapy. We have detected clonal trisomy 5 in two distinct autologous MSC products expanded from bone marrow which, based on the current quality control criteria, could not be released for c...

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Detalles Bibliográficos
Autores principales:	Marodin, Maria Susana Joya, Godoy, Juliana A., Alves-Paiva, Raquel M., Alvarez, Kelen, Mitsugi, Thiago Giove, Krepischi, Ana Cristina Victorino, Hamerschlak, Nelson, Bortolini, Maria Augusta Tezelli, Castro, Rodrigo, Kondo, Andrea T., Kutner, Jose Mauro, Okamoto, Oswaldo Keith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417782/ https://www.ncbi.nlm.nih.gov/pubmed/36035513 http://dx.doi.org/10.1155/2022/1613636

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