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Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children
Multisystem inflammatory syndrome in children (MIS-C) occurs secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A retrospective study, involving 6 tertiary-care centers in Haryana, was conducted to evaluate the clinical features, severity, laboratory findings, and o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417928/ https://www.ncbi.nlm.nih.gov/pubmed/36028606 http://dx.doi.org/10.1007/s12098-022-04328-4 |
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author | Dhaliwal, Maninder Raghunathan, Veena Maheshwari, Prabhat Chugh, Krishan Pal, Hari Satija, Mukul Bhatia, Navin Sharma, Pooja Singh, Manish Singhi, Sunit C. |
author_facet | Dhaliwal, Maninder Raghunathan, Veena Maheshwari, Prabhat Chugh, Krishan Pal, Hari Satija, Mukul Bhatia, Navin Sharma, Pooja Singh, Manish Singhi, Sunit C. |
author_sort | Dhaliwal, Maninder |
collection | PubMed |
description | Multisystem inflammatory syndrome in children (MIS-C) occurs secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A retrospective study, involving 6 tertiary-care centers in Haryana, was conducted to evaluate the clinical features, severity, laboratory findings, and outcomes of patients with MIS-C. Disease severity was graded (mild/moderate/severe) and presence of cardiac abnormalities noted. Patients with and without cardiac abnormalities and with and without severe disease were compared. Forty-eight children with MIS-C were included (median age - 9.5 y). Fever (100%), gastrointestinal (83.3%) and mucocutaneous (50%) symptoms were common. Only 16.7% patients had previous history of documented SARS-CoV-2 infection/contact. Severe disease and cardiac abnormalities were seen in 47.9% and 54.2% patients, respectively. NT-proBNP > 1286.5 pg/mL and thrombocytopenia (≤ 119500/µL) were significant risk factors for severe MIS-C. Forty-five patients (93.8%) recovered and 3 died. Median hospitalization duration was 7 d (5–9.5). MIS-C must be considered as a possibility in any febrile child, even if a positive epidemiological history is absent. High NT-proBNP and thrombocytopenia are significant risk factors for severe MIS-C. (Trial Registration: The study was registered with the Clinical Trials Registry, India (CTRI/2021/09/036491)). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12098-022-04328-4. |
format | Online Article Text |
id | pubmed-9417928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-94179282022-08-30 Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children Dhaliwal, Maninder Raghunathan, Veena Maheshwari, Prabhat Chugh, Krishan Pal, Hari Satija, Mukul Bhatia, Navin Sharma, Pooja Singh, Manish Singhi, Sunit C. Indian J Pediatr Clinical Brief Multisystem inflammatory syndrome in children (MIS-C) occurs secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A retrospective study, involving 6 tertiary-care centers in Haryana, was conducted to evaluate the clinical features, severity, laboratory findings, and outcomes of patients with MIS-C. Disease severity was graded (mild/moderate/severe) and presence of cardiac abnormalities noted. Patients with and without cardiac abnormalities and with and without severe disease were compared. Forty-eight children with MIS-C were included (median age - 9.5 y). Fever (100%), gastrointestinal (83.3%) and mucocutaneous (50%) symptoms were common. Only 16.7% patients had previous history of documented SARS-CoV-2 infection/contact. Severe disease and cardiac abnormalities were seen in 47.9% and 54.2% patients, respectively. NT-proBNP > 1286.5 pg/mL and thrombocytopenia (≤ 119500/µL) were significant risk factors for severe MIS-C. Forty-five patients (93.8%) recovered and 3 died. Median hospitalization duration was 7 d (5–9.5). MIS-C must be considered as a possibility in any febrile child, even if a positive epidemiological history is absent. High NT-proBNP and thrombocytopenia are significant risk factors for severe MIS-C. (Trial Registration: The study was registered with the Clinical Trials Registry, India (CTRI/2021/09/036491)). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12098-022-04328-4. Springer India 2022-08-27 2022 /pmc/articles/PMC9417928/ /pubmed/36028606 http://dx.doi.org/10.1007/s12098-022-04328-4 Text en © The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Clinical Brief Dhaliwal, Maninder Raghunathan, Veena Maheshwari, Prabhat Chugh, Krishan Pal, Hari Satija, Mukul Bhatia, Navin Sharma, Pooja Singh, Manish Singhi, Sunit C. Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title | Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title_full | Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title_fullStr | Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title_full_unstemmed | Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title_short | Severity and Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
title_sort | severity and cardiac involvement in multisystem inflammatory syndrome in children |
topic | Clinical Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417928/ https://www.ncbi.nlm.nih.gov/pubmed/36028606 http://dx.doi.org/10.1007/s12098-022-04328-4 |
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