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Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary

Surface-enhanced Raman scattering (SERS) has been widely used owing to its high sensitivity and rapid response. In particular, 3D SERS-active platforms greatly extend the interaction area and ensure the ability to directly detect trace amounts of molecules in liquids. A silver-coated capillary, with...

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Detalles Bibliográficos
Autores principales: Kang, Chen, Sun, Zhoutao, Fang, Xiaohui, Zha, Lei, Han, Yu, Liu, Hongmei, Guo, Jinxin, Zhang, Xinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418034/
https://www.ncbi.nlm.nih.gov/pubmed/36132359
http://dx.doi.org/10.1039/d1na00593f
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author Kang, Chen
Sun, Zhoutao
Fang, Xiaohui
Zha, Lei
Han, Yu
Liu, Hongmei
Guo, Jinxin
Zhang, Xinping
author_facet Kang, Chen
Sun, Zhoutao
Fang, Xiaohui
Zha, Lei
Han, Yu
Liu, Hongmei
Guo, Jinxin
Zhang, Xinping
author_sort Kang, Chen
collection PubMed
description Surface-enhanced Raman scattering (SERS) has been widely used owing to its high sensitivity and rapid response. In particular, 3D SERS-active platforms greatly extend the interaction area and ensure the ability to directly detect trace amounts of molecules in liquids. A silver-coated capillary, with the ability of liquid sampling and light guiding, provides a new platform for high-performance SERS substrates. In this paper, the silver mirror reaction was used for coating silver on the outer wall of the capillary. PDMS was used as a coating material to protect the silver film. Because of the silver coating, Mie scattering and Raman scattering in the liquid channel can be refocused and reflected back which greatly reduces the propagation loss and extends the interaction length. An enhancement factor as high as 10(8) and a detection limit of 10(−10) M of rhodamine 6G in aqueous solution have been achieved. Moreover, the SERS intensity is homogeneous across the end face of the liquid channel, with the relative standard deviation (RSD) value changing within 7%. The large area and high homogeneity greatly reduce the requirement of light coupling precision and liquid injection pressure. Using a common flange optical fiber connector, the capillary can be simply connected and aligned with a multimode fiber with a detection limit of 10(−8) M. The experiment results show great potential for the development of an optofluidic integrated system in the future.
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spelling pubmed-94180342022-09-20 Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary Kang, Chen Sun, Zhoutao Fang, Xiaohui Zha, Lei Han, Yu Liu, Hongmei Guo, Jinxin Zhang, Xinping Nanoscale Adv Chemistry Surface-enhanced Raman scattering (SERS) has been widely used owing to its high sensitivity and rapid response. In particular, 3D SERS-active platforms greatly extend the interaction area and ensure the ability to directly detect trace amounts of molecules in liquids. A silver-coated capillary, with the ability of liquid sampling and light guiding, provides a new platform for high-performance SERS substrates. In this paper, the silver mirror reaction was used for coating silver on the outer wall of the capillary. PDMS was used as a coating material to protect the silver film. Because of the silver coating, Mie scattering and Raman scattering in the liquid channel can be refocused and reflected back which greatly reduces the propagation loss and extends the interaction length. An enhancement factor as high as 10(8) and a detection limit of 10(−10) M of rhodamine 6G in aqueous solution have been achieved. Moreover, the SERS intensity is homogeneous across the end face of the liquid channel, with the relative standard deviation (RSD) value changing within 7%. The large area and high homogeneity greatly reduce the requirement of light coupling precision and liquid injection pressure. Using a common flange optical fiber connector, the capillary can be simply connected and aligned with a multimode fiber with a detection limit of 10(−8) M. The experiment results show great potential for the development of an optofluidic integrated system in the future. RSC 2021-10-05 /pmc/articles/PMC9418034/ /pubmed/36132359 http://dx.doi.org/10.1039/d1na00593f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kang, Chen
Sun, Zhoutao
Fang, Xiaohui
Zha, Lei
Han, Yu
Liu, Hongmei
Guo, Jinxin
Zhang, Xinping
Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title_full Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title_fullStr Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title_full_unstemmed Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title_short Molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
title_sort molecular trace detection in liquids using refocusing optical feedback by a silver-coated capillary
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418034/
https://www.ncbi.nlm.nih.gov/pubmed/36132359
http://dx.doi.org/10.1039/d1na00593f
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