Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations. The ergosterol biosynthetic pathway has been identified as a drug target in Leishmania. However, remarkable differences in...

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Detalles Bibliográficos
Autores principales: Feng, Mei, Jin, Yiru, Yang, Sihyung, Joachim, Arline M., Ning, Yu, Mori-Quiroz, Luis M., Fromm, Jacob, Perera, Chamani, Zhang, Kai, Werbovetz, Karl A., Wang, Michael Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418051/
https://www.ncbi.nlm.nih.gov/pubmed/35994895
http://dx.doi.org/10.1016/j.ijpddr.2022.07.003

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