Impact of stereotactic body radiotherapy vs palliative radiotherapy on oncologic outcomes of patients with metastatic kidney cancer concomitantly treated with immune checkpoint inhibitors: a preliminary, multicentre experience

PURPOSE: To explore the benefit yielded by radiotherapy (RT), we report a series of metastatic renal cell carcinoma (RCC) patients treated with concomitant RT plus Nivolumab. METHODS/PATIENTS: Patients undergoing Nivolumab treatment plus concomitant RT (ablative or palliative) were included. RT was...

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Detalles Bibliográficos
Autores principales: Francolini, Giulio, Campi, Riccardo, Di Cataldo, Vanessa, Detti, Beatrice, Loi, Mauro, Triggiani, Luca, La Mattina, Salvatore, Borghetti, Paolo, Magrini, Stefano Maria, Nicosia, Luca, Alongi, Filippo, Ghirardelli, Paolo, Vavassori, Vittorio, Allegra, Andrea Gaetano, Aquilano, Michele, Scoccimarro, Erika, Peruzzi, Anna, Pastina, Pierpaolo, Visani, Luca, Desideri, Isacco, Serni, Sergio, Meattini, Icro, Livi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Brief Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418086/
https://www.ncbi.nlm.nih.gov/pubmed/35739349
http://dx.doi.org/10.1007/s12094-022-02844-5
Descripción
Sumario:PURPOSE: To explore the benefit yielded by radiotherapy (RT), we report a series of metastatic renal cell carcinoma (RCC) patients treated with concomitant RT plus Nivolumab. METHODS/PATIENTS: Patients undergoing Nivolumab treatment plus concomitant RT (ablative or palliative) were included. RT was defined Ablative if >5 Gy/fraction were delivered. RESULTS: Ablative RT intent was the only independent predictor of both progression free and overall survival (HR 3.51, 95% CI 1.6–7.5, p = 0.0012 and HR 2.8, 95% CI 0.99–8.07, p = 0.05, respectively). CONCLUSION: Ablative RT may improve oncologic outcomes in selected patients with metastatic RCC treated with Nivolumab as compared to palliative RT.

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