Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer

This commentary article highlights two recently published studies, which for the first time revealed the immunological underpinnings of sex‐bias in cancer incidence and mortality. These studies showed that the androgen receptor restrains anti‐tumour immunity in males by repressing cytotoxic genes in...

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Autores principales: Hussain, Tabinda, Kallies, Axel, Vasanthakumar, Ajithkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418121/
https://www.ncbi.nlm.nih.gov/pubmed/36051310
http://dx.doi.org/10.1002/cti2.1414
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author Hussain, Tabinda
Kallies, Axel
Vasanthakumar, Ajithkumar
author_facet Hussain, Tabinda
Kallies, Axel
Vasanthakumar, Ajithkumar
author_sort Hussain, Tabinda
collection PubMed
description This commentary article highlights two recently published studies, which for the first time revealed the immunological underpinnings of sex‐bias in cancer incidence and mortality. These studies showed that the androgen receptor restrains anti‐tumour immunity in males by repressing cytotoxic genes in CD8(+) T cells.[Image: see text]
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spelling pubmed-94181212022-08-31 Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer Hussain, Tabinda Kallies, Axel Vasanthakumar, Ajithkumar Clin Transl Immunology Commentary This commentary article highlights two recently published studies, which for the first time revealed the immunological underpinnings of sex‐bias in cancer incidence and mortality. These studies showed that the androgen receptor restrains anti‐tumour immunity in males by repressing cytotoxic genes in CD8(+) T cells.[Image: see text] John Wiley and Sons Inc. 2022-08-26 /pmc/articles/PMC9418121/ /pubmed/36051310 http://dx.doi.org/10.1002/cti2.1414 Text en © 2022 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Commentary
Hussain, Tabinda
Kallies, Axel
Vasanthakumar, Ajithkumar
Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title_full Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title_fullStr Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title_full_unstemmed Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title_short Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
title_sort sex‐bias in cd8 (+) t‐cell stemness and exhaustion in cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418121/
https://www.ncbi.nlm.nih.gov/pubmed/36051310
http://dx.doi.org/10.1002/cti2.1414
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