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Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform

Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P)(+)) in biotransformation. However, engineering enzymes to utilize them is challenging. Here, we present a high-throughput directed evolution platform which couples cell growth t...

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Detalles Bibliográficos
Autores principales:	Zhang, Linyue, King, Edward, Black, William B., Heckmann, Christian M., Wolder, Allison, Cui, Youtian, Nicklen, Francis, Siegel, Justin B., Luo, Ray, Paul, Caroline E., Li, Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418148/ https://www.ncbi.nlm.nih.gov/pubmed/36028482 http://dx.doi.org/10.1038/s41467-022-32727-w

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