AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically, its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 deficiency in smooth muscles promotes persistent pulmonary hypertension of the new-born. Accordingly, dual AMPK-α1/α2 deletion...

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Detalles Bibliográficos
Autores principales: Moral-Sanz, Javier, Lewis, Sophronia A., MacMillan, Sandy, Meloni, Marco, McClafferty, Heather, Viollet, Benoit, Foretz, Marc, del-Pozo, Jorge, Mark Evans, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418192/
https://www.ncbi.nlm.nih.gov/pubmed/36028487
http://dx.doi.org/10.1038/s41467-022-32568-7

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