SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression. HGPS patients eventually die by coronary artery disease and cardiovascular alterations. Yet, h...

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Detalles Bibliográficos
Autores principales: Catarinella, Giorgia, Nicoletti, Chiara, Bracaglia, Andrea, Procopio, Paola, Salvatori, Illari, Taggi, Marilena, Valle, Cristiana, Ferri, Alberto, Canipari, Rita, Puri, Pier Lorenzo, Latella, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418244/
https://www.ncbi.nlm.nih.gov/pubmed/36028501
http://dx.doi.org/10.1038/s41419-022-05168-y

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