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Glycosylation and its research progress in endometrial cancer
Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418304/ https://www.ncbi.nlm.nih.gov/pubmed/35752750 http://dx.doi.org/10.1007/s12094-022-02858-z |
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author | Pu, Congli Biyuan Xu, Kai Zhao, Yingchao |
author_facet | Pu, Congli Biyuan Xu, Kai Zhao, Yingchao |
author_sort | Pu, Congli |
collection | PubMed |
description | Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive biomarkers and therapeutic targets is critical to enable the early detection of metastasis and improve the prognosis. For decades, extensive studies had focused on glycans and glycoproteins in the progression of cancer. The types of glycans that are covalently attached to the polypeptide backbone, usually via nitrogen or oxygen linkages, are known as N‑glycans or O‑glycans, respectively. The degree of protein glycosylation and the aberrant changes in the carbohydrate structures have been implicated in the extent of tumorigenesis and reported to play a critical role in regulating tumor invasion, metabolism, and immunity. This review summarizes the essential biological role of glycosylation in EC, with a focus on the recent advances in glycomics and glycosylation markers, highlighting their implications in the diagnosis and treatment of EC. |
format | Online Article Text |
id | pubmed-9418304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-94183042022-08-28 Glycosylation and its research progress in endometrial cancer Pu, Congli Biyuan Xu, Kai Zhao, Yingchao Clin Transl Oncol Review Article Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive biomarkers and therapeutic targets is critical to enable the early detection of metastasis and improve the prognosis. For decades, extensive studies had focused on glycans and glycoproteins in the progression of cancer. The types of glycans that are covalently attached to the polypeptide backbone, usually via nitrogen or oxygen linkages, are known as N‑glycans or O‑glycans, respectively. The degree of protein glycosylation and the aberrant changes in the carbohydrate structures have been implicated in the extent of tumorigenesis and reported to play a critical role in regulating tumor invasion, metabolism, and immunity. This review summarizes the essential biological role of glycosylation in EC, with a focus on the recent advances in glycomics and glycosylation markers, highlighting their implications in the diagnosis and treatment of EC. Springer International Publishing 2022-06-25 2022 /pmc/articles/PMC9418304/ /pubmed/35752750 http://dx.doi.org/10.1007/s12094-022-02858-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Pu, Congli Biyuan Xu, Kai Zhao, Yingchao Glycosylation and its research progress in endometrial cancer |
title | Glycosylation and its research progress in endometrial cancer |
title_full | Glycosylation and its research progress in endometrial cancer |
title_fullStr | Glycosylation and its research progress in endometrial cancer |
title_full_unstemmed | Glycosylation and its research progress in endometrial cancer |
title_short | Glycosylation and its research progress in endometrial cancer |
title_sort | glycosylation and its research progress in endometrial cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418304/ https://www.ncbi.nlm.nih.gov/pubmed/35752750 http://dx.doi.org/10.1007/s12094-022-02858-z |
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