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Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes

Ease of transmission and exceptionally high mortality rates make pathogen-based infections an ongoing global threat. Herein, a facile bacterial elimination process is described which is based on the photodynamic activity of fullerenes composed of light-harvesting antenna molecules integrated into li...

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Detalles Bibliográficos
Autores principales: Kawasaki, Riku, Antoku, Daiki, Ohdake, Reo, Sugikawa, Kouta, Ikeda, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418483/
https://www.ncbi.nlm.nih.gov/pubmed/36132890
http://dx.doi.org/10.1039/d0na00132e
Descripción
Sumario:Ease of transmission and exceptionally high mortality rates make pathogen-based infections an ongoing global threat. Herein, a facile bacterial elimination process is described which is based on the photodynamic activity of fullerenes composed of light-harvesting antenna molecules integrated into liposome membranes. This was done to expand the absorption capabilities of fullerene derivatives. Efficient energy transfer from the photoactivated antenna molecules to the fullerenes enhanced antimicrobial activity without any harmful lytic activity against red blood cells even under irradiation.