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Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

The synthesis of proinflammatory leukotrienes implicated in asthma, allergic rhinitis, and atherosclerosis is initiated by the enzyme 5-lipoxygenase (5-LOX). The crystal structure of human Stable-5-LOX revealed a conformation where the catalytic iron was inaccessible to bulk solvent as two aromatic...

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Detalles Bibliográficos
Autores principales:	Gallegos, Eden M., Reed, Tanner D., Mathes, Forge A., Guevara, Nelson V., Neau, David B., Huang, Wei, Newcomer, Marcia E., Gilbert, Nathaniel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418500/ https://www.ncbi.nlm.nih.gov/pubmed/35863431 http://dx.doi.org/10.1016/j.jbc.2022.102282

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