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Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice
Infant crying is a communicative behavior impaired in neurodevelopmental disorders (NDDs). Because advanced paternal age is a risk factor for NDDs, we performed computational approaches to evaluate how paternal age affected vocal communication and body weight development in C57BL/6 mouse offspring f...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418688/ https://www.ncbi.nlm.nih.gov/pubmed/36039363 http://dx.doi.org/10.1016/j.isci.2022.104834 |
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author | Mai, Lingling Inada, Hitoshi Kimura, Ryuichi Kanno, Kouta Matsuda, Takeru Tachibana, Ryosuke O. Tucci, Valter Komaki, Fumiyasu Hiroi, Noboru Osumi, Noriko |
author_facet | Mai, Lingling Inada, Hitoshi Kimura, Ryuichi Kanno, Kouta Matsuda, Takeru Tachibana, Ryosuke O. Tucci, Valter Komaki, Fumiyasu Hiroi, Noboru Osumi, Noriko |
author_sort | Mai, Lingling |
collection | PubMed |
description | Infant crying is a communicative behavior impaired in neurodevelopmental disorders (NDDs). Because advanced paternal age is a risk factor for NDDs, we performed computational approaches to evaluate how paternal age affected vocal communication and body weight development in C57BL/6 mouse offspring from young and aged fathers. Analyses of ultrasonic vocalization (USV) consisting of syllables showed that advanced paternal age reduced the number and duration of syllables, altered the syllable composition, and caused lower body weight gain in pups. Pups born to young fathers had convergent vocal characteristics with a rich repertoire, whereas those born to aged fathers exhibited more divergent vocal patterns with limited repertoire. Additional analyses revealed that some pups from aged fathers displayed atypical USV trajectories. Thus, our study indicates that advanced paternal age has a significant effect on offspring’s vocal development. Our computational analyses are effective in characterizing altered individual diversity. |
format | Online Article Text |
id | pubmed-9418688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94186882022-08-28 Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice Mai, Lingling Inada, Hitoshi Kimura, Ryuichi Kanno, Kouta Matsuda, Takeru Tachibana, Ryosuke O. Tucci, Valter Komaki, Fumiyasu Hiroi, Noboru Osumi, Noriko iScience Article Infant crying is a communicative behavior impaired in neurodevelopmental disorders (NDDs). Because advanced paternal age is a risk factor for NDDs, we performed computational approaches to evaluate how paternal age affected vocal communication and body weight development in C57BL/6 mouse offspring from young and aged fathers. Analyses of ultrasonic vocalization (USV) consisting of syllables showed that advanced paternal age reduced the number and duration of syllables, altered the syllable composition, and caused lower body weight gain in pups. Pups born to young fathers had convergent vocal characteristics with a rich repertoire, whereas those born to aged fathers exhibited more divergent vocal patterns with limited repertoire. Additional analyses revealed that some pups from aged fathers displayed atypical USV trajectories. Thus, our study indicates that advanced paternal age has a significant effect on offspring’s vocal development. Our computational analyses are effective in characterizing altered individual diversity. Elsevier 2022-08-11 /pmc/articles/PMC9418688/ /pubmed/36039363 http://dx.doi.org/10.1016/j.isci.2022.104834 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Mai, Lingling Inada, Hitoshi Kimura, Ryuichi Kanno, Kouta Matsuda, Takeru Tachibana, Ryosuke O. Tucci, Valter Komaki, Fumiyasu Hiroi, Noboru Osumi, Noriko Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title | Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title_full | Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title_fullStr | Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title_full_unstemmed | Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title_short | Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
title_sort | advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418688/ https://www.ncbi.nlm.nih.gov/pubmed/36039363 http://dx.doi.org/10.1016/j.isci.2022.104834 |
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