Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper

Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses against AAV gene therapies, resulting in comprehensive...

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Detalles Bibliográficos
Autores principales: Yang, Tong-yuan, Braun, Manuela, Lembke, Wibke, McBlane, Fraser, Kamerud, John, DeWall, Stephen, Tarcsa, Edit, Fang, Xiaodong, Hofer, Lena, Kavita, Uma, Upreti, Vijay V., Gupta, Swati, Loo, LiNa, Johnson, Alison J., Chandode, Rakesh Kantilal, Stubenrauch, Kay-Gunnar, Vinzing, Maya, Xia, Cindy Q., Jawa, Vibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418752/
https://www.ncbi.nlm.nih.gov/pubmed/36092368
http://dx.doi.org/10.1016/j.omtm.2022.07.018

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