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Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate buildup

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that induces diverse biological and toxic effects, including reprogramming intermediate metabolism, mediated by the aryl hydrocarbon receptor. However, the specific reprogramming effects of TCDD are unclear. Here, w...

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Detalles Bibliográficos
Autores principales:	Orlowska, Karina, Fling, Russ R., Nault, Rance, Sink, Warren J., Schilmiller, Anthony L., Zacharewski, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418907/ https://www.ncbi.nlm.nih.gov/pubmed/35931118 http://dx.doi.org/10.1016/j.jbc.2022.102301

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