Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles

Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels–Alder reaction of a ‘caged’ tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, whil...

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Detalles Bibliográficos
Autores principales: Baker, Daina V., Arafeh, Khaled M., Asadirad, Amir, Kaur, Brahmjot, Raza, Rameez, Branda, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419036/
https://www.ncbi.nlm.nih.gov/pubmed/36134313
http://dx.doi.org/10.1039/d1na00289a
Descripción
Sumario:Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels–Alder reaction of a ‘caged’ tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, while the byproduct of the reaction is trapped in the hydrophobic layer of the nano-assembly.

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