Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles

Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels–Alder reaction of a ‘caged’ tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, whil...

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Detalles Bibliográficos
Autores principales: Baker, Daina V., Arafeh, Khaled M., Asadirad, Amir, Kaur, Brahmjot, Raza, Rameez, Branda, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419036/
https://www.ncbi.nlm.nih.gov/pubmed/36134313
http://dx.doi.org/10.1039/d1na00289a
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author Baker, Daina V.
Arafeh, Khaled M.
Asadirad, Amir
Kaur, Brahmjot
Raza, Rameez
Branda, Neil R.
author_facet Baker, Daina V.
Arafeh, Khaled M.
Asadirad, Amir
Kaur, Brahmjot
Raza, Rameez
Branda, Neil R.
author_sort Baker, Daina V.
collection PubMed
description Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels–Alder reaction of a ‘caged’ tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, while the byproduct of the reaction is trapped in the hydrophobic layer of the nano-assembly.
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spelling pubmed-94190362022-09-20 Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles Baker, Daina V. Arafeh, Khaled M. Asadirad, Amir Kaur, Brahmjot Raza, Rameez Branda, Neil R. Nanoscale Adv Chemistry Visible light is used to generate heat from gold nanoparticles wrapped in an amphiphilic polymer shell and trigger a reverse Diels–Alder reaction of a ‘caged’ tyrphostin therapeutic agent. The hydrophilic nature of the released agent results in it travelling from the polymer to the bulk medium, while the byproduct of the reaction is trapped in the hydrophobic layer of the nano-assembly. RSC 2021-07-02 /pmc/articles/PMC9419036/ /pubmed/36134313 http://dx.doi.org/10.1039/d1na00289a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Baker, Daina V.
Arafeh, Khaled M.
Asadirad, Amir
Kaur, Brahmjot
Raza, Rameez
Branda, Neil R.
Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title_full Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title_fullStr Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title_full_unstemmed Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title_short Photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
title_sort photothermal release of an encapsulated therapeutic agent from polymer-wrapped gold nanoparticles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419036/
https://www.ncbi.nlm.nih.gov/pubmed/36134313
http://dx.doi.org/10.1039/d1na00289a
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