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Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) fo...

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Autores principales: Hwang, Jangsun, Zheng, Mengjia, Wiraja, Christian, Cui, Mingyue, Yang, Lixia, Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419214/
https://www.ncbi.nlm.nih.gov/pubmed/36132036
http://dx.doi.org/10.1039/d0na00572j
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author Hwang, Jangsun
Zheng, Mengjia
Wiraja, Christian
Cui, Mingyue
Yang, Lixia
Xu, Chenjie
author_facet Hwang, Jangsun
Zheng, Mengjia
Wiraja, Christian
Cui, Mingyue
Yang, Lixia
Xu, Chenjie
author_sort Hwang, Jangsun
collection PubMed
description Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings.
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spelling pubmed-94192142022-09-20 Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts Hwang, Jangsun Zheng, Mengjia Wiraja, Christian Cui, Mingyue Yang, Lixia Xu, Chenjie Nanoscale Adv Chemistry Macrophages can be polarized to M1 or M2 type with pro-inflammatory or anti-inflammatory properties. Nanoparticles have recently been found to be a promising platform to polarize macrophages to desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency of this technology are examined via cytokine analysis and immunostaining of the nanoghost-treated cells. We find that several cytokines/chemokines are highly expressed on nanoghosts. In addition, a 2D wound healing model is deployed to reveal their potential application in clinical settings. RSC 2020-09-09 /pmc/articles/PMC9419214/ /pubmed/36132036 http://dx.doi.org/10.1039/d0na00572j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hwang, Jangsun
Zheng, Mengjia
Wiraja, Christian
Cui, Mingyue
Yang, Lixia
Xu, Chenjie
Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title_full Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title_fullStr Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title_full_unstemmed Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title_short Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
title_sort reprogramming of macrophages with macrophage cell membrane-derived nanoghosts
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419214/
https://www.ncbi.nlm.nih.gov/pubmed/36132036
http://dx.doi.org/10.1039/d0na00572j
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