ALEX versus ISAC multiplex array in analyzing food allergy in atopic children

ALEX multiplex array is a relatively new multiplex allergy test which analyses more than 120 allergen extracts and 170 molecular components. ISAC is the most used and studied multiplex array to date, offering 112 molecular components. In ten atopic children with multiple food allergies good agreemen...

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Autores principales: Sonneveld, Laura J. H., Emons, Joyce A. M., Arends, Nicolette J. T., Landzaat, Lonneke J., Veenbergen, Sharon, Schreurs, Marco W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419344/
https://www.ncbi.nlm.nih.gov/pubmed/36030246
http://dx.doi.org/10.1186/s12948-022-00177-w
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author Sonneveld, Laura J. H.
Emons, Joyce A. M.
Arends, Nicolette J. T.
Landzaat, Lonneke J.
Veenbergen, Sharon
Schreurs, Marco W. J.
author_facet Sonneveld, Laura J. H.
Emons, Joyce A. M.
Arends, Nicolette J. T.
Landzaat, Lonneke J.
Veenbergen, Sharon
Schreurs, Marco W. J.
author_sort Sonneveld, Laura J. H.
collection PubMed
description ALEX multiplex array is a relatively new multiplex allergy test which analyses more than 120 allergen extracts and 170 molecular components. ISAC is the most used and studied multiplex array to date, offering 112 molecular components. In ten atopic children with multiple food allergies good agreement was observed between ALEX and ISAC sIgE results for nearly all shared food components. Presence of larger number of allergens in ALEX could help clinicians to improve personalized dietary advice. However more positive sensitizations with unknown clinical relevance were found by ALEX, potentially increasing clinical complexity. Pediatric allergists should be aware of this, especially in young atopic children with (severe) eczema who have not introduced all sorts of food yet.
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spelling pubmed-94193442022-08-28 ALEX versus ISAC multiplex array in analyzing food allergy in atopic children Sonneveld, Laura J. H. Emons, Joyce A. M. Arends, Nicolette J. T. Landzaat, Lonneke J. Veenbergen, Sharon Schreurs, Marco W. J. Clin Mol Allergy Letters to the Editor ALEX multiplex array is a relatively new multiplex allergy test which analyses more than 120 allergen extracts and 170 molecular components. ISAC is the most used and studied multiplex array to date, offering 112 molecular components. In ten atopic children with multiple food allergies good agreement was observed between ALEX and ISAC sIgE results for nearly all shared food components. Presence of larger number of allergens in ALEX could help clinicians to improve personalized dietary advice. However more positive sensitizations with unknown clinical relevance were found by ALEX, potentially increasing clinical complexity. Pediatric allergists should be aware of this, especially in young atopic children with (severe) eczema who have not introduced all sorts of food yet. BioMed Central 2022-08-27 /pmc/articles/PMC9419344/ /pubmed/36030246 http://dx.doi.org/10.1186/s12948-022-00177-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letters to the Editor
Sonneveld, Laura J. H.
Emons, Joyce A. M.
Arends, Nicolette J. T.
Landzaat, Lonneke J.
Veenbergen, Sharon
Schreurs, Marco W. J.
ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title_full ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title_fullStr ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title_full_unstemmed ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title_short ALEX versus ISAC multiplex array in analyzing food allergy in atopic children
title_sort alex versus isac multiplex array in analyzing food allergy in atopic children
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419344/
https://www.ncbi.nlm.nih.gov/pubmed/36030246
http://dx.doi.org/10.1186/s12948-022-00177-w
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