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Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis

BACKGROUND & AIMS: The COVID-19 pandemic has had a major negative impact on health systems and many chronic diseases globally. We aimed to evaluate the impact of the first year of the pandemic on the outcomes of people with NAFLD cirrhosis. METHODS: We conducted a before-after study in four Univ...

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Autores principales: Rivera-Esteban, Jesús, Manzano-Nuñez, Ramiro, Broquetas, Teresa, Serra-Matamala, Isabel, Bassegoda, Octavi, Soriano-Varela, Agnès, Espín, Gemma, Castillo, Joaquín, Bañares, Juan, Carrión, José A., Ginès, Pere, Graupera, Isabel, Pericàs, Juan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419430/
https://www.ncbi.nlm.nih.gov/pubmed/36061511
http://dx.doi.org/10.1016/j.jhepr.2022.100574
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author Rivera-Esteban, Jesús
Manzano-Nuñez, Ramiro
Broquetas, Teresa
Serra-Matamala, Isabel
Bassegoda, Octavi
Soriano-Varela, Agnès
Espín, Gemma
Castillo, Joaquín
Bañares, Juan
Carrión, José A.
Ginès, Pere
Graupera, Isabel
Pericàs, Juan M.
author_facet Rivera-Esteban, Jesús
Manzano-Nuñez, Ramiro
Broquetas, Teresa
Serra-Matamala, Isabel
Bassegoda, Octavi
Soriano-Varela, Agnès
Espín, Gemma
Castillo, Joaquín
Bañares, Juan
Carrión, José A.
Ginès, Pere
Graupera, Isabel
Pericàs, Juan M.
author_sort Rivera-Esteban, Jesús
collection PubMed
description BACKGROUND & AIMS: The COVID-19 pandemic has had a major negative impact on health systems and many chronic diseases globally. We aimed to evaluate the impact of the first year of the pandemic on the outcomes of people with NAFLD cirrhosis. METHODS: We conducted a before-after study in four University hospitals in Catalonia, Spain. Study subperiods were divided into Pre-pandemic (March/2019–February/2020) vs. Pandemic (March/2020–February/2021). The primary outcome was the rate of first liver-related event (LRE). Overall clinical outcomes (LREs plus cardiovascular plus all-cause mortality) were also assessed. RESULTS: A total of 354 patients were included, all of whom were compensated at the beginning of the study period; 83 individuals (23.5%) had a history of prior hepatic decompensation. Mean age was 67.3 years and 48.3% were female. Median BMI was 31.2 kg/m(2) and type 2 diabetes was present in 72.8% of patients. The rates of first LRE in the Pre-pandemic and Pandemic periods were 7.4% and 11.3% (p = 0.12), respectively. Whilst the rate of overall events was significantly higher in the Pandemic period (9.9% vs. 17.8%; p = 0.009), this was strongly associated with COVID-19-related deaths. The rate of worsened metabolic status was significantly higher in the Pandemic period (38.4% vs. 46.1%; p = 0.041), yet this was not associated with the risk of first LRE during the Pandemic period, whereas type 2 diabetes (odds ratio [OR] 3.77; 95% CI 1.15–12.32; p = 0.028), albumin <4 g/L (OR 4.43; 95% CI 1.76–11.17; p = 0.002) and Fibrosis-4 score >2.67 (OR 15.74; 95% CI 2.01–123.22; p = 0.009) were identified as risk factors in the multivariable analysis. CONCLUSION: Overall, people with NAFLD cirrhosis did not present poorer liver-related outcomes during the first year of the pandemic. Health system preparedness seems key to ensure that people with NAFLD cirrhosis receive appropriate care during health crises. LAY SUMMARY: Mobility restrictions and social stress induced by the COVID-19 pandemic have led to increased alcohol drinking and worsened metabolic control (e.g., weight gain, poor control of diabetes) in a large proportion of the population in many countries. We aimed to analyze whether people with cirrhosis due to non-alcoholic fatty liver disease, who are particularly vulnerable to such lifestyle modifications, were significantly impacted during the first year of the pandemic. We compared the clinical situation of 354 patients one year before the pandemic and one year after. We found that although metabolic control was indeed worse after the first year of the pandemic and patients presented worse clinical outcomes, the latter was mostly due to non-liver causes, namely COVID-19 itself. Moreover, the care provided to these patients did not worsen during the first year of the pandemic.
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spelling pubmed-94194302022-08-30 Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis Rivera-Esteban, Jesús Manzano-Nuñez, Ramiro Broquetas, Teresa Serra-Matamala, Isabel Bassegoda, Octavi Soriano-Varela, Agnès Espín, Gemma Castillo, Joaquín Bañares, Juan Carrión, José A. Ginès, Pere Graupera, Isabel Pericàs, Juan M. JHEP Rep Research Article BACKGROUND & AIMS: The COVID-19 pandemic has had a major negative impact on health systems and many chronic diseases globally. We aimed to evaluate the impact of the first year of the pandemic on the outcomes of people with NAFLD cirrhosis. METHODS: We conducted a before-after study in four University hospitals in Catalonia, Spain. Study subperiods were divided into Pre-pandemic (March/2019–February/2020) vs. Pandemic (March/2020–February/2021). The primary outcome was the rate of first liver-related event (LRE). Overall clinical outcomes (LREs plus cardiovascular plus all-cause mortality) were also assessed. RESULTS: A total of 354 patients were included, all of whom were compensated at the beginning of the study period; 83 individuals (23.5%) had a history of prior hepatic decompensation. Mean age was 67.3 years and 48.3% were female. Median BMI was 31.2 kg/m(2) and type 2 diabetes was present in 72.8% of patients. The rates of first LRE in the Pre-pandemic and Pandemic periods were 7.4% and 11.3% (p = 0.12), respectively. Whilst the rate of overall events was significantly higher in the Pandemic period (9.9% vs. 17.8%; p = 0.009), this was strongly associated with COVID-19-related deaths. The rate of worsened metabolic status was significantly higher in the Pandemic period (38.4% vs. 46.1%; p = 0.041), yet this was not associated with the risk of first LRE during the Pandemic period, whereas type 2 diabetes (odds ratio [OR] 3.77; 95% CI 1.15–12.32; p = 0.028), albumin <4 g/L (OR 4.43; 95% CI 1.76–11.17; p = 0.002) and Fibrosis-4 score >2.67 (OR 15.74; 95% CI 2.01–123.22; p = 0.009) were identified as risk factors in the multivariable analysis. CONCLUSION: Overall, people with NAFLD cirrhosis did not present poorer liver-related outcomes during the first year of the pandemic. Health system preparedness seems key to ensure that people with NAFLD cirrhosis receive appropriate care during health crises. LAY SUMMARY: Mobility restrictions and social stress induced by the COVID-19 pandemic have led to increased alcohol drinking and worsened metabolic control (e.g., weight gain, poor control of diabetes) in a large proportion of the population in many countries. We aimed to analyze whether people with cirrhosis due to non-alcoholic fatty liver disease, who are particularly vulnerable to such lifestyle modifications, were significantly impacted during the first year of the pandemic. We compared the clinical situation of 354 patients one year before the pandemic and one year after. We found that although metabolic control was indeed worse after the first year of the pandemic and patients presented worse clinical outcomes, the latter was mostly due to non-liver causes, namely COVID-19 itself. Moreover, the care provided to these patients did not worsen during the first year of the pandemic. Elsevier 2022-08-27 /pmc/articles/PMC9419430/ /pubmed/36061511 http://dx.doi.org/10.1016/j.jhepr.2022.100574 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Rivera-Esteban, Jesús
Manzano-Nuñez, Ramiro
Broquetas, Teresa
Serra-Matamala, Isabel
Bassegoda, Octavi
Soriano-Varela, Agnès
Espín, Gemma
Castillo, Joaquín
Bañares, Juan
Carrión, José A.
Ginès, Pere
Graupera, Isabel
Pericàs, Juan M.
Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title_full Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title_fullStr Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title_full_unstemmed Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title_short Impact of the COVID-19 pandemic on the care and outcomes of people with NAFLD-related cirrhosis
title_sort impact of the covid-19 pandemic on the care and outcomes of people with nafld-related cirrhosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419430/
https://www.ncbi.nlm.nih.gov/pubmed/36061511
http://dx.doi.org/10.1016/j.jhepr.2022.100574
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