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Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers

The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in es...

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Detalles Bibliográficos
Autores principales: Capistrán, Marcos A., Capella, Antonio, Christen, J. Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/
https://www.ncbi.nlm.nih.gov/pubmed/36075125
http://dx.doi.org/10.1016/j.epidem.2022.100624
Descripción
Sumario:The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico.