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Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in es...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/ https://www.ncbi.nlm.nih.gov/pubmed/36075125 http://dx.doi.org/10.1016/j.epidem.2022.100624 |
Sumario: | The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico. |
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