Cargando…
Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in es...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/ https://www.ncbi.nlm.nih.gov/pubmed/36075125 http://dx.doi.org/10.1016/j.epidem.2022.100624 |
_version_ | 1784777175139876864 |
---|---|
author | Capistrán, Marcos A. Capella, Antonio Christen, J. Andrés |
author_facet | Capistrán, Marcos A. Capella, Antonio Christen, J. Andrés |
author_sort | Capistrán, Marcos A. |
collection | PubMed |
description | The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico. |
format | Online Article Text |
id | pubmed-9419436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94194362022-08-30 Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers Capistrán, Marcos A. Capella, Antonio Christen, J. Andrés Epidemics Article The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico. The Authors. Published by Elsevier B.V. 2022-09 2022-08-27 /pmc/articles/PMC9419436/ /pubmed/36075125 http://dx.doi.org/10.1016/j.epidem.2022.100624 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Capistrán, Marcos A. Capella, Antonio Christen, J. Andrés Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title | Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title_full | Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title_fullStr | Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title_full_unstemmed | Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title_short | Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers |
title_sort | filtering and improved uncertainty quantification in the dynamic estimation of effective reproduction numbers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/ https://www.ncbi.nlm.nih.gov/pubmed/36075125 http://dx.doi.org/10.1016/j.epidem.2022.100624 |
work_keys_str_mv | AT capistranmarcosa filteringandimproveduncertaintyquantificationinthedynamicestimationofeffectivereproductionnumbers AT capellaantonio filteringandimproveduncertaintyquantificationinthedynamicestimationofeffectivereproductionnumbers AT christenjandres filteringandimproveduncertaintyquantificationinthedynamicestimationofeffectivereproductionnumbers |