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Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers

The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in es...

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Autores principales: Capistrán, Marcos A., Capella, Antonio, Christen, J. Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/
https://www.ncbi.nlm.nih.gov/pubmed/36075125
http://dx.doi.org/10.1016/j.epidem.2022.100624
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author Capistrán, Marcos A.
Capella, Antonio
Christen, J. Andrés
author_facet Capistrán, Marcos A.
Capella, Antonio
Christen, J. Andrés
author_sort Capistrán, Marcos A.
collection PubMed
description The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico.
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spelling pubmed-94194362022-08-30 Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers Capistrán, Marcos A. Capella, Antonio Christen, J. Andrés Epidemics Article The effective reproduction number [Formula: see text] measures an infectious disease’s transmissibility as the number of secondary infections in one reproduction time in a population having both susceptible and non-susceptible hosts. Current approaches do not quantify the uncertainty correctly in estimating [Formula: see text] , as expected by the observed variability in contagion patterns. We elaborate on the Bayesian estimation of [Formula: see text] by improving on the Poisson sampling model of Cori et al. (2013). By adding an autoregressive latent process, we build a Dynamic Linear Model on the log of observed [Formula: see text] s, resulting in a filtering type Bayesian inference. We use a conjugate analysis, and all calculations are explicit. Results show an improved uncertainty quantification on the estimation of [Formula: see text] ’s, with a reliable method that could safely be used by non-experts and within other forecasting systems. We illustrate our approach with recent data from the current COVID19 epidemic in Mexico. The Authors. Published by Elsevier B.V. 2022-09 2022-08-27 /pmc/articles/PMC9419436/ /pubmed/36075125 http://dx.doi.org/10.1016/j.epidem.2022.100624 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Capistrán, Marcos A.
Capella, Antonio
Christen, J. Andrés
Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title_full Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title_fullStr Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title_full_unstemmed Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title_short Filtering and improved Uncertainty Quantification in the dynamic estimation of effective reproduction numbers
title_sort filtering and improved uncertainty quantification in the dynamic estimation of effective reproduction numbers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419436/
https://www.ncbi.nlm.nih.gov/pubmed/36075125
http://dx.doi.org/10.1016/j.epidem.2022.100624
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