Cargando…

Nanolipoprotein particles for co-delivery of cystine-knot peptides and Fab–based therapeutics

Nanolipoprotein particles (NLPs) have been evaluated as an in vivo delivery vehicle for a variety of molecules of therapeutic interest. However, delivery of peptide-like drugs in combination with therapeutic Fabs has not yet been evaluated. In this study, we describe the development and characteriza...

Descripción completa

Detalles Bibliográficos
Autores principales:	Darwish, Martine, Gao, Xinxin, Shatz, Whitney, Li, Hong, Lin, May, Franke, Yvonne, Tam, Christine, Mortara, Kyle, Zilberleyb, Inna, Hannoush, Rami N., Blanchette, Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9419673/ https://www.ncbi.nlm.nih.gov/pubmed/36133017 http://dx.doi.org/10.1039/d1na00218j

Ejemplares similares

Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking
por: Gao, Xinxin, et al.
Publicado: (2016)

Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide
por: Gao, Xinxin, et al.
Publicado: (2021)

Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy
por: Gao, Xinxin, et al.
Publicado: (2019)

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling
por: Hansen, Simon, et al.
Publicado: (2022)

Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform
por: Fischer, Nicholas O., et al.
Publicado: (2014)

Characterization and Purification of Polydisperse Reconstituted Lipoproteins and Nanolipoprotein Particles
por: Blanchette, Craig D., et al.
Publicado: (2009)

Isolation, Characterization, and Stability of Discretely-Sized Nanolipoprotein Particles Assembled with Apolipophorin-III
por: Fischer, Nicholas O., et al.
Publicado: (2010)

Cystine Knot Peptides with Tuneable Activity and Mechanism
por: Li, Choi Yi, et al.
Publicado: (2022)

KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007
por: Gracy, Jérôme, et al.
Publicado: (2008)

Targeting the tumor vasculature with engineered cystine-knot miniproteins
por: Lui, Bonny Gaby, et al.
Publicado: (2020)

Killer Knots: Molecular Evolution of Inhibitor Cystine Knot Toxins in Wandering Spiders (Araneae: Ctenidae)
por: Brewer, Michael S., et al.
Publicado: (2023)

Novel Inhibitor Cystine Knot Peptides from Momordica charantia
por: He, Wen-Jun, et al.
Publicado: (2013)

High Proteolytic Resistance of Spider-Derived Inhibitor Cystine Knots
por: Kikuchi, Kyoko, et al.
Publicado: (2015)

The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge
por: Weilhammer, Dina R., et al.
Publicado: (2013)

Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles
por: Coleman, Matthew A., et al.
Publicado: (2016)

A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging
por: Jiang, Lei, et al.
Publicado: (2014)

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold
por: Gao, Bin, et al.
Publicado: (2013)

Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides
por: Hellinger, Roland, et al.
Publicado: (2021)

Characterization of De Novo Synthesized GPCRs Supported in Nanolipoprotein Discs
por: Gao, Tingjuan, et al.
Publicado: (2012)

Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots
por: Gracy, Jérôme, et al.
Publicado: (2010)

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus
por: Lal, Sangeet, et al.
Publicado: (2017)

(111)In-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis
por: Jiang, Lei, et al.
Publicado: (2012)

Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1
por: Glotzbach, Bernhard, et al.
Publicado: (2013)

Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition
por: Boschert, Verena, et al.
Publicado: (2013)

Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
por: Retzl, Bernhard, et al.
Publicado: (2020)

Fragmentation Follows Structure: Top-Down Mass Spectrometry Elucidates the Topology of Engineered Cystine-Knot Miniproteins
por: Reinwarth, Michael, et al.
Publicado: (2014)

Correction: Mutational Analysis of Sclerostin Shows Importance of the Flexible Loop and the Cystine-Knot for Wnt-Signaling Inhibition
por: Boschert, Verena, et al.
Publicado: (2014)

The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a
por: Herzig, Volker, et al.
Publicado: (2015)

‘Double-muscling’ and pelvic tilt phenomena in rabbits with the cystine-knot motif deficiency of myostatin on exon 3
por: Zhang, Ting, et al.
Publicado: (2019)

A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future
por: Holz, Emily, et al.
Publicado: (2023)

Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines
por: Iyer, Shalini, et al.
Publicado: (2011)

Functional Mutation of Multiple Solvent-Exposed Loops in the Ecballium elaterium Trypsin Inhibitor-II Cystine Knot Miniprotein
por: Kimura, Richard H., et al.
Publicado: (2011)

Expression and Biological Activity of the Cystine Knot Bioinsecticide PA1b (Pea Albumin 1 Subunit b)
por: Eyraud, Vanessa, et al.
Publicado: (2013)

KNOTTIN: the database of inhibitor cystine knot scaffold after 10 years, toward a systematic structure modeling
por: Postic, Guillaume, et al.
Publicado: (2018)

Chemical Synthesis, Backbone Cyclization and Oxidative Folding of Cystine-knot Peptides — Promising Scaffolds for Applications in Drug Design
por: Reinwarth, Michael, et al.
Publicado: (2012)

Stability and Safety of Inhibitor Cystine Knot Peptide, GTx1-15, from the Tarantula Spider Grammostola rosea
por: Kimura, Tadashi
Publicado: (2021)

Nanolipoprotein-Mediated Her2 Protein Transfection Induces Malignant Transformation in Human Breast Acinar Cultures
por: He, Wei, et al.
Publicado: (2021)

Engineering Agatoxin, a Cystine-Knot Peptide from Spider Venom, as a Molecular Probe for In Vivo Tumor Imaging
por: Moore, Sarah J., et al.
Publicado: (2013)

Initial description of primate-specific cystine-knot Prometheus genes and differential gene expansions of D-dopachrome tautomerase genes
por: Premzl, Marko
Publicado: (2015)

Evaluation of integrin αvβ(6) cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis
por: Kimura, Richard H., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p1bi2g2ut03nbo2iduqb5cbmon