The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

The SARS-CoV-2 variants B.1.617.1 (Kappa) contain multiple mutations in the spike protein. However, the effect of B.1.617.1 lineage-related mutants on viral infectivity and inactivated-virus vaccine efficacy remains to be defined. We therefore constructed 12 B.1.617.1-related pseudoviruses and syste...

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Autores principales: Yang, Xinyi, Zhu, Yuqi, Xun, Jingna, Liu, Jun, Wen, Qing, Lin, Yixiao, Shen, Xiaoting, Chen, Jun, Yuan, Songhua, Zhao, Xiaying, Wang, Jing, Pan, Hanyu, Yang, Jinlong, Liang, Zhiming, Liang, Yue, Lin, Qinru, Liang, Huitong, Zhou, Chunyan, Jin, Li, Xie, Weijian, Liu, Jianping, Lu, Daru, Ying, Tianlei, Shen, Yinzhong, Zhang, Xiaoyan, Xu, Jianqing, Yin, Chunhua, Wang, Pengfei, Jiang, Shibo, Lu, Hongzhou, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420027/
https://www.ncbi.nlm.nih.gov/pubmed/36062074
http://dx.doi.org/10.1016/j.isci.2022.105016
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author Yang, Xinyi
Zhu, Yuqi
Xun, Jingna
Liu, Jun
Wen, Qing
Lin, Yixiao
Shen, Xiaoting
Chen, Jun
Yuan, Songhua
Zhao, Xiaying
Wang, Jing
Pan, Hanyu
Yang, Jinlong
Liang, Zhiming
Liang, Yue
Lin, Qinru
Liang, Huitong
Zhou, Chunyan
Jin, Li
Xie, Weijian
Liu, Jianping
Lu, Daru
Ying, Tianlei
Shen, Yinzhong
Zhang, Xiaoyan
Xu, Jianqing
Yin, Chunhua
Wang, Pengfei
Jiang, Shibo
Lu, Hongzhou
Zhu, Huanzhang
author_facet Yang, Xinyi
Zhu, Yuqi
Xun, Jingna
Liu, Jun
Wen, Qing
Lin, Yixiao
Shen, Xiaoting
Chen, Jun
Yuan, Songhua
Zhao, Xiaying
Wang, Jing
Pan, Hanyu
Yang, Jinlong
Liang, Zhiming
Liang, Yue
Lin, Qinru
Liang, Huitong
Zhou, Chunyan
Jin, Li
Xie, Weijian
Liu, Jianping
Lu, Daru
Ying, Tianlei
Shen, Yinzhong
Zhang, Xiaoyan
Xu, Jianqing
Yin, Chunhua
Wang, Pengfei
Jiang, Shibo
Lu, Hongzhou
Zhu, Huanzhang
author_sort Yang, Xinyi
collection PubMed
description The SARS-CoV-2 variants B.1.617.1 (Kappa) contain multiple mutations in the spike protein. However, the effect of B.1.617.1 lineage-related mutants on viral infectivity and inactivated-virus vaccine efficacy remains to be defined. We therefore constructed 12 B.1.617.1-related pseudoviruses and systematically studied the effects of mutations on virus infectivity and neutralization resistance to convalescent and inactivated virus vaccine sera. Our results show that the B.1.617.1 variant exhibited both higher infectivity and neutralization resistance in sera at 1 or 3 months after vaccination of 28 individuals and at 14 and 200 days after discharge of 15 convalescents. Notably, 89% of vaccines and 100% of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against one single mutation: E484Q. Besides, we found a significant decrease in neutralizing activity in convalescent patients and BBIBP-CorV vaccines for B.1.1.529. These findings demonstrate that inactivated-virus vaccination or convalescent sera showed reduced, but still significant, neutralization against the B.1.617.1 variant.
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spelling pubmed-94200272022-08-30 The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines Yang, Xinyi Zhu, Yuqi Xun, Jingna Liu, Jun Wen, Qing Lin, Yixiao Shen, Xiaoting Chen, Jun Yuan, Songhua Zhao, Xiaying Wang, Jing Pan, Hanyu Yang, Jinlong Liang, Zhiming Liang, Yue Lin, Qinru Liang, Huitong Zhou, Chunyan Jin, Li Xie, Weijian Liu, Jianping Lu, Daru Ying, Tianlei Shen, Yinzhong Zhang, Xiaoyan Xu, Jianqing Yin, Chunhua Wang, Pengfei Jiang, Shibo Lu, Hongzhou Zhu, Huanzhang iScience Article The SARS-CoV-2 variants B.1.617.1 (Kappa) contain multiple mutations in the spike protein. However, the effect of B.1.617.1 lineage-related mutants on viral infectivity and inactivated-virus vaccine efficacy remains to be defined. We therefore constructed 12 B.1.617.1-related pseudoviruses and systematically studied the effects of mutations on virus infectivity and neutralization resistance to convalescent and inactivated virus vaccine sera. Our results show that the B.1.617.1 variant exhibited both higher infectivity and neutralization resistance in sera at 1 or 3 months after vaccination of 28 individuals and at 14 and 200 days after discharge of 15 convalescents. Notably, 89% of vaccines and 100% of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against one single mutation: E484Q. Besides, we found a significant decrease in neutralizing activity in convalescent patients and BBIBP-CorV vaccines for B.1.1.529. These findings demonstrate that inactivated-virus vaccination or convalescent sera showed reduced, but still significant, neutralization against the B.1.617.1 variant. Elsevier 2022-08-27 /pmc/articles/PMC9420027/ /pubmed/36062074 http://dx.doi.org/10.1016/j.isci.2022.105016 Text en © 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yang, Xinyi
Zhu, Yuqi
Xun, Jingna
Liu, Jun
Wen, Qing
Lin, Yixiao
Shen, Xiaoting
Chen, Jun
Yuan, Songhua
Zhao, Xiaying
Wang, Jing
Pan, Hanyu
Yang, Jinlong
Liang, Zhiming
Liang, Yue
Lin, Qinru
Liang, Huitong
Zhou, Chunyan
Jin, Li
Xie, Weijian
Liu, Jianping
Lu, Daru
Ying, Tianlei
Shen, Yinzhong
Zhang, Xiaoyan
Xu, Jianqing
Yin, Chunhua
Wang, Pengfei
Jiang, Shibo
Lu, Hongzhou
Zhu, Huanzhang
The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title_full The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title_fullStr The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title_full_unstemmed The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title_short The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines
title_sort neutralization of b.1.617.1 and b.1.1.529 sera from convalescent patients and bbibp-corv vaccines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420027/
https://www.ncbi.nlm.nih.gov/pubmed/36062074
http://dx.doi.org/10.1016/j.isci.2022.105016
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