Misfolded protein oligomers induce an increase of intracellular Ca(2+) causing an escalation of reactive oxidative species

Alzheimer's disease is characterized by the accumulation in the brain of the amyloid β (Aβ) peptide in the form of senile plaques. According to the amyloid hypothesis, the aggregation process of Aβ also generates smaller soluble misfolded oligomers that contribute to disease progression. One of...

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Detalles Bibliográficos
Autores principales: Fani, Giulia, La Torre, Chiara Ester, Cascella, Roberta, Cecchi, Cristina, Vendruscolo, Michele, Chiti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420098/
https://www.ncbi.nlm.nih.gov/pubmed/36030306
http://dx.doi.org/10.1007/s00018-022-04513-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420098/
https://www.ncbi.nlm.nih.gov/pubmed/36030306
http://dx.doi.org/10.1007/s00018-022-04513-w

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