Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that glucose-mediated changes in gene expression largely persist in diabetic kidney disease (DKD) despite reversing hyperglycemia. The senescence-associated cyclin-dependent kinase inh...

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Detalles Bibliográficos
Autores principales: Al-Dabet, Moh’d Mohanad, Shahzad, Khurrum, Elwakiel, Ahmed, Sulaj, Alba, Kopf, Stefan, Bock, Fabian, Gadi, Ihsan, Zimmermann, Silke, Rana, Rajiv, Krishnan, Shruthi, Gupta, Dheerendra, Manoharan, Jayakumar, Fatima, Sameen, Nazir, Sumra, Schwab, Constantin, Baber, Ronny, Scholz, Markus, Geffers, Robert, Mertens, Peter Rene, Nawroth, Peter P., Griffin, John H., Keller, Maria, Dockendorff, Chris, Kohli, Shrey, Isermann, Berend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420151/
https://www.ncbi.nlm.nih.gov/pubmed/36030260
http://dx.doi.org/10.1038/s41467-022-32477-9

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